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37 results for “Dengue”
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Research ArticleOpen accessEvery word in the titleIn Silico Analysis of Envelope Dengue Virus-2 and Envelope Dengue Virus-3 Protein as the Backbone of Dengue Virus Tetravalent Vaccine by Using Homology Modeling MethodUsman Sumo Friend Tambunan, Arli Aditya Parikesit, Hendra et al.Problem statement: Dengue fever, which was caused by Dengue virus infection, had became a major public health problem in the tropic and subtropical countries. Dengue virus (DENV) had four serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), based on their immunogenic in the human body. Preventive measure will be necessary to decrease the prevalence of dengue fever, by developing modern vaccine. Approach: … …OnLine Journal of Biological Sciences, Vol. 9, Issue 1 · 3 Sep 2010 · 9,265 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDengue during Pregnancy: A Study of Thirteen CasesChristiane Fernandes Alvarenga, Vânia Glória Silami, Patrícia Brasil et al.Problem statement: The principal aim was to evaluate the effects of dengue virus infection by dengue during pregnancy and analyze the histopathology of the placenta. Approach: A retrospective study was conducted with 13 pregnant women with dengue confirmed in the period from January-December 2002, during a widespread dengue type 3 epidemic in Rio de Janeiro. Maternal and newborn data were … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 8,993 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleC-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular MimicryShu-Wen Wan, Chiou-Feng Lin, Mei-Chun Chen et al.Infection with dengue virus (DV) causes diseases ranging from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia and bleeding are the clinical manifestations associated with dengue hemorrhage. We previously showed that anti-DV nonstructural protein 1 (NS1) antibodies (Abs) cross-reacted with endothelial cells. The potential target proteins on endothelial cell surface recognized by anti-DV … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,560 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEpitope Mapping of Dengue-Virus-Enhancing Monoclonal-Antibody Using Phage Display Peptide LibraryChung-I Rai, Huan-Yao Lei, Yee-Shin Lin et al.The Antibody-Dependent Enhancement (ADE) hypothesis has been proposed to explain why more severe manifestations of Dengue Hemorrhagic Fever and Dengue Shock Syndrome (DHF/DSS) occur predominantly during secondary infections of Dengue Virus (DV) with different serotypes. However, the epitopes recognized by these enhancing antibodies are unclear. Recently, antipre-M monoclonal antibody (mAb 70-21), which recognized all DV serotypes without neutralizing activity, were … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 8,453 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePatient and Mouse Antibodies against Dengue Virus Nonstructural Protein 1 Cross-React with Platelets and Cause Their Dysfunction or DepletionChiou-Feng Lin, Huan-Yao Lei, Ching-Chuan Liu et al.Thrombocytopenia is a clinical manifestation in dengue virus (DV) infection, yet its pathogenic mechanisms are unresolved. We previously showed that dengue patient sera contained antibodies cross-reactive with platelets. In this study, we demonstrated that the anti-platelet activity of dengue patient sera was due to the antibodies against DV nonstructural protein 1 (NS1). Studies using DV-infected or recombinant NS1-immunized mouse sera … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,321 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnti-Platelet and Anti-Endothelial Cell Autoantibodies in Vietnamese Infants and Children with Dengue Hemorrhagic FeverNguyen Thanh Hung, Nguyen Trong Lan, Yee-Shin Lin et al.Dengue hemorrhagic fever (DHF) is a serious public health problem. Increased vascular permeability and thrombocytopenia are the hallmarks of DHF. The mechanisms involved in DHF/Dengue shock syndrome (DSS) pathogenesis is not fully understood. This study gives evidence of the presence of antibodies which cross-reacted with platelets, and endothelial cells in the sera of Vietnamese infants and children with DHF/DSS. The … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,369 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSignaling Pathways Involved In Dengue-2 Virus Infection Induced RANTES OverexpressionYing-Ray Lee, Huan-Yao Lei, Shun-Hua Chen et al.Dengue viruses participate in liver inflammation by inducting the expression of various chemokines including Regulated on Activation Normal T-cell Expressed and Secreted (RANTES). However, the underlying signaling remains unknown. Here, we reveal that Ras, Raf-1 and three mitogen-activated protein kinases (MAPKs) p38, extracellular signal-regulated kinase (Erk), and c-jun-NH2-terminal kinase (JNK) can be activated or phosphorylated in dengue-2 virus infected hepatocyte … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,173 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCorrelation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue PatientsYing-Ray Lee, Nguyen-Thanh Hung, Ching-Chuan Liu et al.Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,051 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHigh Case-Fatality Rate of Adults With Dengue Hemorrhagic Fever During An Outbreak In Non-Endemic Taiwan: Risk Factors For Dengue-Infected EldersChing-Chuan Liu, Kao-Jean Huang, Mei-Chih Huang et al.In 2002, a dengue outbreak occurred in Taiwan with 5336 confirmed cases, 242 DHF and 21 death, the case fatality rate reached 8.7% (21/242). The demographic data of these age-specific dengue patients showed that dengue virus infection caused symptom primarily occurred in adults. A comparative analysis of clinical and laboratory data for DF, DHF/DSS and fatal DSS found that high … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 8,002 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImmunopathogenesis of Dengue Hemorrhagic FeverHuan-Yao Lei, Kao-Jean Huang, Yee-Shin Lin et al.Dengue virus infection causes Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) whose pathogeneses were not clearly understood. A new hypothesis of immunopathogenesis is proposed for the development of the DHF/DSS. An aberrant immune over-activation after dengue virus infection not only impair the immune response to clear the virus, but also result in overproduction of cytokines … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 14,762 accessesView PDFCite