Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients
Ying-Ray Lee1, Nguyen-Thanh Hung2, Ching-Chuan Liu3, Kao-Jean Huang3, Huan-Yao Lei3, Yee-Shin Lin3, Jen-Reng Wang3, Trai-Ming Yeh3, Shun-Hua Chen3 & Hsiao-Sheng Liu3 Show affiliations
- Institute of Basic Medical Sciences, Vietnam
- Children’s Hospital No. 1, Ho Chi Minh City, Vietnam
- National Cheng Kung University, Taiwan
American Journal of Infectious Diseases, Volume 4, Issue 1, pp. 18–21 · doi.org/10.3844/ajidsp.2008.18.21
Abstract
Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.
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Lee, Y., Hung, N., Liu, C., Huang, K., Lei, H., Lin, Y., Wang, J., Yeh, T., Chen, S. & Liu, H. (2008). Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients. American Journal of Infectious Diseases, 4(1), 18–21. https://doi.org/10.3844/ajidsp.2008.18.21
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