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82 articles for “Clinical Trial”
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Research ArticleOpen accessIn the keywordsMesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and FutureEmma Ghazaryan, Shurong Wang, Yan Zhang et al.Retinal degenerations are the main causes of irreversible blindness in developed countries. Up to date the main pathological mechanisms of these diseases are not fully understood and consequently there is no complete treatment option for those diseases. In this aspect stem cells have drawn attention of many researchers and health care professionals. Considering ethical issues, safety and facile isolation Mesenchymal … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 28 Nov 2014 · 6,766 accessesView PDFCite
Research ArticleOpen accessIn the keywordsImpact of Proven Viral Load on Common Cold Patients Treated with Pelargonium sidoides Preparation EPs 7630Tilman Keck, Andreas Strobl, Andreas Weinhaeusel, Berenike StrackeThe Common Cold (CC) is an acute respiratory tract disorder with viral etiology in at least 90% of the cases. Nevertheless, molecular diagnostic testing often confirms the presence of viral Nucleic Acids (NA) in only about half of the patients. Based on the results of a non-comparative, interventional multicenter study we compare the course of CC between patients with and … …American Journal of Infectious Diseases, Vol. 14, Issue 3 · 13 Nov 2018 · 8,402 accessesView PDFCite
Review ArticleOpen accessIn the keywords"Ebola Ça Suffit!" is not enough to Prove Efficacy of an Ebola VaccineDavid R CroweA recently published Ebola vaccine trial claimed an almost perfect result with no cases of Ebola after the vaccine had time to take effect - a vaccine efficacy of 100%. This article is a detailed review of the information published about the trial and, particularly, this claim. The trial design was sub-optimal because randomization was only partial (and one treatment … …American Journal of Immunology, Vol. 13, Issue 3 · 8 Jul 2017 · 17,825 accessesView PDFCite
Research ArticleOpen accessIn the keywordsTweaking Exponential Distribution to Estimate the Chance for More Survival Time if a Cancerous Kidney is RemovedRamalingam ShanmugamPatients with a malignant tumor in the kidney (recognized as hypernephroma in medical practice) are treated by what is known as nephrectomy (that is a surgical removal of the kidney) in addition to a combionation of chemotherapy and immunotherapy for the sake of more survival time. This articles develops and demonstrates a statistical methodology to assess the statistical significance of … …International Journal of Research in Nursing, Vol. 4, Issue 2 · 4 Sep 2013 · 6,218 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of CTLA-4 Inhibitor Combined with Chemotherapy on Immunoglobulin Levels and General Condition in Breast Cancer PatientsRuiguang CaiThis study conducted an evaluation of the CTLA-4 inhibitor ipilimumab plus standard chemotherapy on immunoglobulin levels, performance status, and Quality of Life (QoL) in patients with stage I-III Breast Cancer (BC) via a randomized controlled trial. 120 patients with stage I-III BC were randomly allocated to the experimental group (chemotherapy + ipilimumab) and the control group (chemotherapy), and the treatment … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 3 Jul 2026 · 1,115 accessesView PDFCite
Literature ReviewOpen accessIn the abstractRemineralization Potential of Bioactive Composite Resins: A Systematic ReviewLuiza Maria Schneider, Maria Ritha Veiga Colognese, Poliana Maria de Faveri Cardoso et al.To evaluate the clinical performance and potential of giomer-based materials in promoting the remineralization of dental structures through a systematic review of the literature. A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases up to March 2024. “giomer,” “S-PRG,” “bioactive restorative materials,” “remineralization,” and “dental caries.” Inclusion criteria comprised clinical studies involving human subjects, with … …Current Research in Dentistry, Vol. 17, Issue 1 · 29 Jan 2026 · 3,135 accessesView PDFCite
Case ReportOpen accessIn the abstractAcyclovir May Be Used to Treat Certain Long COVID Patients Regardless of Herpesvirus Reactivation: Case ReportDenise Stewart, Martin Oswald SavageFundamental causes of long COVID or Post-Acute Sequelae of COVID-19 (PASC) are still under investigation while it remains a significant burden to millions of patients worldwide even after a relatively mild acute Coronavirus Disease 2019 (COVID-19) episode. Treatment and management programs are yet to be developed. The foremost hypotheses for underlying PASC pathophysiology include: The persistence of the virus in … …American Journal of Infectious Diseases, Vol. 20, Issue 1 · 12 Mar 2024 · 25,572 accessesView PDFCite
Review ArticleOpen accessIn the abstractDrug Repositioning in Response to COVID-19 and other Challenging DiseasesHyellavala Joseph Fomnya, Saidu Ibrahim Ngulde, Sarah Malgwi Gana et al.Coronavirus disease is a highly contagious infection that is majorly associated with upper respiratory tract illnesses. The World Health Organization (WHO) label the novel coronavirus disease COVID-19 after an epidemic of the disease in Wuhan, Hubei province (China). Over 90 clinical trials, including drug repositioning, have been initiated to get COVID-19 treatment/management. Antibiotic resistance, drug tolerance, mutation, and adverse drug … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 28 Nov 2022 · 9,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Remdesivir with Poor Clinical Outcomes in COVID-19-A Single Center ExperienceRajat Ranka, Arjun, Prasan Kumar Panda et al.The need for an antiviral against COVID-19 prompted clinical trials worldwide and based on initial promising trends, remdesivir was widely used, including in India (compassionate use). Subsequent trials have been conflicting in their results and the utility of the drug has been widely debated. This is a record-based retrospective cohort study in a 1000-bedded government teaching hospital in North India. … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 3 Jun 2022 · 7,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Essential Oils Versus Home Remedies on Relieving Signs of Acute Respiratory Tract Infection among ChildrenAbeer Abd El-Aziz Mohamed Madian, Mohammad Mahmoud Abd-Alhaseeb, Ebtsam Salah Yonis Mahrous, Rodaina Ahmed MokbelAcute Respiratory Infection (ARI) accounts for more than 94 million cases annually and 1.9 million deaths among children worldwide. ARI is the most common cause of illness and mortality in children under five years old. The purpose of this study was to investigate the effect of essential oils versus home remedies on relieving signs and symptoms of ARI among children. … …American Journal of Infectious Diseases, Vol. 17, Issue 1 · 27 Feb 2021 · 7,357 accessesView PDFCite