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82 articles for “Breast Cancer”
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Research ArticleOpen accessPhrase in the titleRelative Transcription Expression Level of SIRT1, SIRT2 and SIRT3 in Correlation to the Expression of a Set of Selected Cancer Related Genes in Human Breast CancerHamdy Swelim, Omnia Mansour, Salah Abdel-Rahman et al.Mammalian Sirtuins have been shown to perform distinct cellular functions and deregulated expression of these genes was reported to be involved in the development of various malignancies including breast cancer. An increasing number of evidence indicates that Sirtuins have both tumor promoter and tumor suppressor functions. However, the roles of Sirtuins have not been well-studied in breast cancer. In the … …OnLine Journal of Biological Sciences, Vol. 18, Issue 2 · 18 Jan 2018 · 7,476 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleStudying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast CancerDmitry Sergeevich Kravchenko, Yuriy Nikolaevich Lezhnin, Anna Evgenyevna Ivanova et al.Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed а comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number … …OnLine Journal of Biological Sciences, Vol. 17, Issue 2 · 3 Jun 2017 · 7,419 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCrosstalk between Oxidative Stress Signaling and HER2 Pathway in Breast CancerVanessa Jacob Victorino, Adriano Martin Felis Aranome, Fernanda Carolina de Campos et al.About 20% of breast cancer patients overexpress the Human Epidermal growth factor Receptor-2 (HER2), also known as ErbB2. HER2-overexpression is associated with enhanced tumor malignancy and its overexpression is related to specific target therapy against breast tumors and other cancers. HER2-mediated pathways in tumor cells act on behalf of the tumor conferring aggressive characteristics. Several reports demonstrated the occurrence of … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,038 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe Participation of Oxidative Stress in Breast Cancer Cells Progression and Treatment ResistancePoliana Camila Marinello, Kaliana Larissa Machado, Rubens Cecchini, Alessandra Lourenço CecchiniThis article presents a general discussion about the participation of oxidative stress in relevant points related to breast cancer progression in vitro. All of the evidences presented here are based on published papers that used breast cancer cells with different phenotype characteristics in their research. We observed that oxidative stress could modulate by several manners the tumor progression and these … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 7,511 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCommunity Pharmacists’ Involvement in Breast Cancer Health Promotion in United Arab Emirates (UAE)Osama H. Mohamed Ibrahim, Rana M. IbrahimBreast cancer is the most common cancer in women in Middle East countries. Despite the continuous efforts to increase the public awareness of breast cancer via campaigns and public screening programs, breast cancer screening rate remains low. The participation of community pharmacists in the communication and dissemination of breast cancer screening information should have a significant positive impact. The objectives … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 29 Oct 2013 · 8,122 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleNew Computer Aided Detection Method for the Effective Detection of Breast CancerBalasubramaniam Senthilkumar, Govindaswamy UmamaheswariAnalyzing mammogram images is the most challenging task for radiologists in detecting breast cancer. Computer Aided Detection (CAD) plays major role in detecting such disease. Preprocessing, segmentation and detection are the processes involved in CAD. In this study, we have designed a CAD by improving the processes for the effective detection for breast cancer. Selective median filter has been used … …OnLine Journal of Biological Sciences, Vol. 12, Issue 4 · 13 Mar 2013 · 7,174 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleNovel Preprocessing Technique in the Computer Aided Detection of Breast CancerSenthilkumar Balasubramaniam, Umamaheswari GovindaswamyAnalyzing medical images is the most challenging task in medical image processing. Computer Aided Detection (CAD) tool is the aid for the radiologists in analyzing such images for the effective detection and diagnosis of the disease. Such a CAD tool consists of Preprocessing, Segmentation and detection processes. In this study we have improved the preprocessing by using the Selective Median … …Journal of Computer Science, Vol. 8, Issue 12 · 8 Nov 2012 · 6,650 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleQuercetin in Dimethyl Benzanthracene Induced Breast Cancer in RatsNatla Sashidhar Reddy, Parthasarathy Nirmala, Natesan Chidambaram, Pammi Ashok kumarProblem statement: Vincristine a commonly used anticancer agent in the treatment of breast cancer results in serious adverse effects like teratogenicity, neurotoxicity and carcinogenicity on long term use. Drug resistance is also a common problem encountered with vincristine. Hence the effect of flavonol quercetin, a known antioxidant with no known documented adverse effect was tried in treatment of DMBA induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 30 Jul 2012 · 8,138 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCross Validation Evaluation for Breast Cancer Prediction Using Multilayer Perceptron Neural NetworksShirin A. Mojarad, Satnam S. Dlay, Wai L. Woo, Gajanan V. SherbetProblem statement: The presence of metastasis in the regional lymph nodes is the most important factor in predicting prognosis in breast cancer. Many biomarkers have been identified that appear to relate to the aggressive behaviour of cancer. However, the nonlinear relation of these markers to nodal status and also the existence of complex interaction between markers have prohibited an accurate … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 4 · 20 Feb 2012 · 7,699 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEarly Diagnosis of Breast Cancer using Molecular, Biochemical and Pathological MarkersSalah El-Din El-Assal, Adel A. El-Tarras, Samir M. Abd-allaProblem statement: Laboratory diagnosis of breast cancer in most of the hospitals has traditionally been performed using cell culture and the direct hormone receptor assay, which are money and time consuming. Approach: This study was performed in order to direct the attention toward increasing the efficiency of early diagnosis in clinical laboratories at the western region of KSA and Egypt … …American Journal of Applied Sciences, Vol. 8, Issue 1 · 31 Jan 2011 · 8,056 accessesView PDFCite