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Research Article · Open access · Published 3 June 2017

Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer

Dmitry Sergeevich Kravchenko1, Yuriy Nikolaevich Lezhnin2, Anna Evgenyevna Ivanova1, Yulia Evgenyevna Kravchenko1 & Elena Ivanovna Frolova1

OnLine Journal of Biological Sciences, Volume 17, Issue 2, pp. 50–57 · doi.org/10.3844/ojbsci.2017.50.57

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Abstract

Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed а comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we found CD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.

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Kravchenko, D. S., Lezhnin, Y. N., Ivanova, A. E., Kravchenko, Y. E. & Frolova, E. I. (2017). Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer. OnLine Journal of Biological Sciences, 17(2), 50–57. https://doi.org/10.3844/ojbsci.2017.50.57

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Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast CancerOnLine Journal of Biological Sciences · Volume 17, Issue 2 · pp. 50–57 · CC BY 3.0Download