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181 articles for “Receptor”
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EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractDUAL ROLES OF CANCER CELL-EXPRESSED IMMUNOGLOBULINS IN CANCER IMMUNOLOGYGregory Lee, Cheng-Yuan Huang, Suefay Liu et al.While the expression of immunoglobulins and T cell receptors on cancer cells has been well-established for decades, the potential roles and mechanisms of action of these cancerous antigen receptors have not been fully elucidated. A monoclonal antibody designated as RP215, which reacts specifically with the carbohydrate-associated epitope located on the heavy chain region of cancerous immunoglobulins and T cell receptors, … …American Journal of Immunology, Vol. 10, Issue 3 · 2 Oct 2014 · 7,870 accessesView PDFCite
Research ArticleOpen accessIn the abstractInnate, Adaptive and Intrinsic Immunity in Human Immunodeficiency Virus InfectionSuneth S. Perera, Nitin K. SaksenaThe first line of defence of the innate immune system functions by recognizing highly conserved sets of molecular structures specific to the microbes, termed pathogen-associated molecular patterns, or PAMPs via the germ line-encoded receptors Pattern-Recognition Receptors (PRRs). In addition to the innate immune system, the vertebrates have also evolved a second line of defence termed adaptive immune system, which uses … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 27 Nov 2012 · 9,727 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Cell to Cell Interaction of Breast Cancer Cells Regulates Cancer Invasion Via ADAM15Daichi Ota, Masahiro Ikesue, Yutaka Matsui et al.Increasing evidence suggests that a disintegrin and metalloproteinase 15 (ADAM15) have essential roles in the process of cancer metastasis via degradation of the extracellular matrix and binding to integrins. Among them, ADAM15 possesses an Arg-Gly-Asp (RGD) sequence within its disintegrin domain (d.d., hereafter) and binds to RGD recognizing-integrins such as αvβ3 and α5β1 and also interacts with integrin α9β1 in … …American Journal of Immunology, Vol. 8, Issue 4 · 17 Oct 2012 · 7,690 accessesView PDFCite
Research ArticleOpen accessIn the abstractInnate and Adaptative Immunity in the Sea-Star Asterias RubensMichel LeclercThe axial organ of the sea star Asterias rubens is a primitive immune organ. The B-like cells, when stimulated by various antigens, produce antibody substances correlating with Mouse Ig Kappa genes. On the other hand elements of the innate immunity are present in Asterias rubens such as Toll-like receptors, interleukin receptors, complement components which contribute to initiate the «antibody factor». …American Journal of Immunology, Vol. 8, Issue 3 · 1 Sep 2012 · 7,905 accessesView PDFCite
Research ArticleOpen accessIn the abstractDiphenylhydantoin Promotes Proliferation in The Subventricular Zone and Dentate GyrusAlma Y. Galvez-Contreras, Rocio E. Gonzalez-Castaneda, Sonia Luquin et al.Problem statement: Diphenylhydantoin (phenytoin) is an antiepileptic drug that generates hyperplasia in some tissue by stimulating Epidermal Growth Factor (EGFR) and Platelet-Derived Growth Factor beta (PDGFR-β) receptors and by increasing serum levels of basic fibroblast growth factor (bFGF, FGF2 or FGF-β). Neural stem cells in the adult brain have been isolated from three regions: the Subventricular Zone (SVZ) lining the … …Neuroscience International, Vol. 3, Issue 1 · 6 Mar 2012 · 9,141 accessesView PDFCite
Research ArticleOpen accessIn the abstractCross Validation Evaluation for Breast Cancer Prediction Using Multilayer Perceptron Neural NetworksShirin A. Mojarad, Satnam S. Dlay, Wai L. Woo, Gajanan V. SherbetProblem statement: The presence of metastasis in the regional lymph nodes is the most important factor in predicting prognosis in breast cancer. Many biomarkers have been identified that appear to relate to the aggressive behaviour of cancer. However, the nonlinear relation of these markers to nodal status and also the existence of complex interaction between markers have prohibited an accurate … …American Journal of Engineering and Applied Sciences, Vol. 4, Issue 4 · 20 Feb 2012 · 7,703 accessesView PDFCite
Research ArticleOpen accessIn the abstractOlfactory Responses of the Asiatic Citrus Psyllid (Diaphorina citri) to Mineral Oil-Treated Mandarin LeavesMofit Eko Poerwanto, Y. Andi Trisyono, G. Andrew C. Beattie et al.Problem statement: Evidence of rejection or acceptance by phytophagous pests of citrus plants treated with mineral oils suggests that impacts of oils may be related to detection by olfactory and/or contact chemoreceptors of repellent oils or plant volatiles. Alternatively, the oils may mask or suppress attractant host plant volatiles. To date, no studies have reported that oils elicit an olfactory … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 1 · 30 Jan 2012 · 8,785 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanisms of Anti-Cancer Effects of Vernonia amygdalina Leaf ExtractUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Vernonia amygdalina (V. amygdalina) has been shown to have cancer cell inhibition and cytotoxic effects. Approach: This study discusses the multi-faceted and multi-linked mechanisms by which cancer tissue inhibition and destruction is achieved by V. amygdalina leaf extract and powder (subsequently called V. amygdalina Extract). Cancer cell inhibition by V. amygdalina is suggested to occur through inhibition of … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Oct 2011 · 9,093 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Body Calming and Body Vitalizing Effects of Vernonia Amygdalina Leaf Extract and Leaf Powder and their MechanismsUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Vernonia amygdalina (V. amygdalina) leaf soup is regarded by the indigenous Igbo people of South Eastern Nigeria as their best leafy vegetable soup. Despite the bitterness of the bitter leaf soup, the native eaters of the soup feel very content when they eat pounded carbohydrate foods with it. Oral V. amygdalina leaf extract was taken methodically in this … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 3 · 20 Sep 2011 · 8,165 accessesView PDFCite