Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

161 results for “Mice”
Set a search alert
Research ArticleOpen accessIn the abstractPalmitate-Induced Translocation of Caveolin-3 and Endothelial Nitric Oxide Synthase in CardiomyocytesCatherine J. Knowles, Megan Dionne, Martina Cebova, Ilka M. PinzProblem statement: Palmitate is a known cardiac lipotoxin that blunts cardiomyocyte contractile function and induces apoptosis, likely via accumulation of the lipotoxic ceramide. Ceramide is a sphingolipid and localizes to caveolae, which are lined in the inner membrane leaflet by caveolin proteins. In this study, we investigated the effects of palmitate on caveolin proteins and on endothelial Nitric Oxide Synthase … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 27 Aug 2011 · 7,894 accessesView PDFCite
Research ArticleOpen accessIn the abstractStress-Strain Analysis of Abdominal Aortic Wall: A Case of 3D Geometry SimulationP. Khamdaengyodtai, P. Sakulchangsatjatai, P. TerdtoonProblem statement: This study analyzed stress-strain of abdominal aortic wall in 3D geometry simulation. Abdominal aorta is a portion of the aorta vessel in the abdomen which many cardiovascular diseases often occur. Approach: Abdominal aortic wall was considered as 1 layers-3 dimensional cylindrical geometry and homogeneous, incompressible and anisotropic material. Deformation of aortic wall was elastic deformation. Numerical method was … …Energy Research Journal, Vol. 1, Issue 2 · 31 Oct 2010 · 7,406 accessesView PDFCite
Research ArticleOpen accessIn the abstractPreliminary Study on Immunomodulatory Effect of Sarang-Semut Tubers Myrmecodia tuberosa and Myrmecodia pendensTriana Hertiani, Ediati Sasmito, Sumardi, Maria UlfahProblem Statement: Sarang-Semut tubers, Myrmecodia tuberosa and M. pendens (Rubiaceae) are both medicinal plants originating from Papua which have broad range of therapeutic values including those to improve vitality. Nevertheless, no scientific proof is available so far on their immunomodulatory effect. The purpose of this study was to reveal the potency of Sarang-Semut tubers as immunomodulatory agent by evaluating their … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 13,397 accessesView PDFCite
Research ArticleOpen accessIn the abstractMutagenic Screening of Crude Oil Fractions Using Modified Ames Test and Allium cepa (Linn) AssayOlufunsho Awodele, Alade Akintonwa, Sunday O. Olayemi et al.Problem statement: Crude oil which may be broadly characterized as paraffinic or naphthenic is a complex mixture of alkanes, cycloalkanes and aromatic hydrocarbons. About 500,000 workers are employed in crude oil exploration and production worldwide. There have been reports of occupational exposure during drilling, pumping and transportation of crude oil, including maintenance of equipment used for these processes. Thus, skin … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Jan 2010 · 8,629 accessesView PDFCite
Research ArticleOpen accessIn the abstractCross Reactivity between Dromedary Whey Proteins and IgG Anti Bovine α-Lactalbumin and Anti Bovine β-LactoglobulinN. Youcef, D. Saidi, F. Mezemaze et al.Problem statement: Our aim was to enhance the data on antigenic properties of dromedary whey proteins. Approach: The identification of the whey proteins was carried by SDS-page and Reversed phase high performance liquid chromatography (RP-HPLC). The cross-reactivity of dromedary whey proteins with IgG anti bovine β-lactoglobulin and anti bovine α-lactalbumin, obtained by immunisation of Balb/c mice, was carried out by … …American Journal of Applied Sciences, Vol. 6, Issue 8 · 31 Aug 2009 · 7,429 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalgesic and Antioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. LeavesS.M. Raquibul Hasan, Mariam Jamila, Muntasir Mamun Majumder et al.Problem statement: Mikania scandens (L.) Willd., a medicinal plant, is popularly used as herbal remedy for various ailments in Bangladesh. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of the plant. Approach: The analgesic … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 12,542 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,518 accessesView PDFCite
Research ArticleOpen accessIn the abstractIncreased Copper-Mediated Oxidation of Membrane Phosphatidylethanolamine in AutismAbha Chauhan, Ashfaq M. Sheikh, Ved ChauhanWe have previously reported that levels of phosphatidylethanolamine (PE) in the erythrocyte membrane and of ceruloplasmin, a copper-transport antioxidant protein, in the serum are lower in children with autism than in control subjects. In the present study, we report that (a) copper oxidizes and reduces the levels of membrane PE and (b) copper-mediated oxidation of PE is higher in lymphoblasts … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,205 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancer may be caused by the Immune ReactionRichmond T. PrehnHormesis-like effects of immunity have been documented during tumor-growth experiments in mice, quantitatively large immune-reactions have inhibited while lesser quantities of the same specific immune-reactants have been stimulatory to the growth of implanted tumors. Likewise, carcinogenesis has been inhibited by a high quantities of immune reactants, but positively stimulated by lower levels of the same reactants. One observation suggests that … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,460 accessesView PDFCite
Research ArticleOpen accessIn the abstractC-Terminal Region of Dengue Virus Nonstructural Protein 1 Is Involved in Endothelial Cell Cross-Reactivity via Molecular MimicryShu-Wen Wan, Chiou-Feng Lin, Mei-Chun Chen et al.Infection with dengue virus (DV) causes diseases ranging from self-limited dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome. Vascular leakage, thrombocytopenia and bleeding are the clinical manifestations associated with dengue hemorrhage. We previously showed that anti-DV nonstructural protein 1 (NS1) antibodies (Abs) cross-reacted with endothelial cells. The potential target proteins on endothelial cell surface recognized by anti-DV … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,560 accessesView PDFCite