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Research ArticleOpen accessIn the abstractSorbitol-Induced Diabetic-Like Retinal Lesions in Rats: Microscopic StudyGaber A. RamadanThe present study investigated the sorbitol toxicity on the retinas of normal albino rats and founded by the light microscope that intra-peritoneal injection of Sorbitol (10-mg/kg-body weight per day) for 24 weeks produced similar diabetic like retinal lesions in these rats. The retinopathic effects of sorbitol injection affect retinal microvessels, pigment epithelium, neural retina and glial cells. Cytoplasmic vacuolation of … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,630 accessesView PDFCite
Research ArticleOpen accessIn the abstractNaloxone benzoylhydrazone activates Extracellular Signal-Regulated Protein Kinases and modulates Nociceptin Opioid Peptide Receptor activityDeepak R. Thakker, Ghazi F. Altememi, Chitra D. Mandyam et al.Naloxone benzoylhydrazone (NalBzoH) is often used as a nociceptin opioid peptide (NOP) receptor antagonist. However, NalBzoH is also a mixed μ antagonist/κ and δ opioid agonist and its actions at the NOP receptor range from an antagonist to partial agonist, depending on the effector response/system studied. We now report that NalBzoH activates endogenously expressed κ3 opioid, but not NOP, receptors … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,549 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Novel Heat Shock Transcription Factor Family in Entamoeba histolyticaConsuelo G. García, Ma. De la Luz Macias Argüelles, D. Guillermo P Ishiwara et al.The HSTF is a master molecule involved in the transcriptional control of several genes during different types of stress. This transcription factor is a very conserved protein identified in different organisms from bacterial to human. Entamoeba histolytica is the protozoan responsible for the human amoebiasis. This parasite is exposed to different kind of stress as changes in the pH, temperature, … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,182 accessesView PDFCite
Research ArticleOpen accessIn the abstractVibrio cholerae O1 Strains of Different Ribotypes have Similar hlyA RFLP Patterns but Different Vacuolating AbilityJorge E. Vidal, Paula Figueroa-Arredondo, Silvia Giono-Cerezo et al.Extensive cytoplasmic vacuolation on Vero and HeLa cells in vitro by the Vibrio cholerae pore forming toxin HlyA, has been previously reported by our group. Vibrio cholerae O1 and non-O1 pathogenic strains show differences in the potential to induce vacuolation, here we study occurring variations on vacuolating cytotoxic ability, related to changes in the nucleotide sequence of the hlyA-orf. A … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,984 accessesView PDFCite
Research ArticleOpen accessIn the abstractHIV-1-Specific CTL Recognizing a Scarce Epitope Are Not Suppressed by HIV-1 Protease InhibitorsOtto O. YangHIV-1-protease inhibitors have received growing attention as agents that can affect proteases in human proteasomes, with potentially deleterious effects for HIV-1-specific cellular immunity. Studying the antiviral activity of HIV-1-specific CTL that recognize an epitope that is presented at limiting concentrations on infected cells, we find that several HIV-1 protease inhibitors do not affect their function. These data indicate that these … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 7,016 accessesView PDFCite
Research ArticleOpen accessIn the abstractRemoval and Recovery of Uranium using Microorganisms Isolated from North American Uranium DepositsTakehiko TsurutaSome attempts were made to remove and recover uranium that may be present in nuclear fuel effluents and mine tailings using microorganisms isolated from North American uranium deposits. To establish which microorganisms accumulate the most uranium, hundreds strains of microorganisms were screened. Of these strains of microorganisms tested, extremely high uranium accumulating ability was found in some bacteria isolated from … …American Journal of Environmental Sciences, Vol. 3, Issue 2 · 30 Jun 2007 · 7,285 accessesView PDFCite
Research ArticleOpen accessIn the abstractHistological Study of the Caecal Tonsil in the Cecum of 4- 6 Months of Age White Leghorn ChicksM. Rezaian, S. HamediCecum, the largest part of chicken’s large intestine, has an important role in liquid absorption and cellulose digestion. It acts as a defensive organ as well due to the presence of large masses of diffuse and nodular lymphatic tissue in lamina propria and sub mucosa. The cecal tonsil activity has been proved to be depended on the activity of bursa … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Jun 2007 · 8,067 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of pH on the Conformation and Biological Activity of Clostridium septicum Alpha-toxin, a Pore-forming HemolysinB.M. Hang'ombe, T. Kohda, M. Mukamoto, S. KozakiThe effects of pH on the pore-forming Clostridium septicum alpha-toxin that causes myonecrosis was assessed at pH 5.0, 7.0 and 9.0 by measuring circular dichroism and its biological activity. Incubation of the toxin at pH 5.0 increased the hemolytic activity measured in murine red blood cells. On the other hand, incubation of the toxin at pH 9.0 drastically reduces the … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Jun 2007 · 6,902 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiomedicine and Informatics Model of Alzheimer's DiseaseKang Cheng, Chang-Hua ZouIn a perspective of biomedicine and informatics, the mechanism of Alzheimer's, senile amnesia, or other aging-associated and cognitive impairment related diseases involve four important informative processing procedures: propagation, consolidation, retrieval and cognition, In this study, we systematically model the four procedures based on published experimental data. When modeling the propagation, we develop an equivalent circuit of biological membrane to describe … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 28 May 2007 · 6,824 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Efficient Ant Algorithm for Swarm-Based Image ClusteringSalima Ouadfel, Mohamed BatoucheA collective approach to resolve the segmentation problem was proposed. AntClust is a new ant-based algorithm that uses the self-organizing and autonomous brood sorting behavior observed in real ants. Ants and pixels are scatted on a discrete array of cells represented the ants’ environment. Using simple local rules and without any central control, ants form homogeneous clusters by moving pixels … …Journal of Computer Science, Vol. 3, Issue 3 · 31 Mar 2007 · 7,155 accessesView PDFCite