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132 articles for “toxic effect”
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Research ArticleOpen accessIn the abstractClozapine and its Major Stable Metabolites, N-desmethylclozapine and Clozapine N-oxide do not Affect Human Bone Marrow Stromal Cells in vitroAvril Pereira, Brian DeanTreatment of refractory schizophrenia with the atypical antipsychotic drug clozapine is associated with life-threatening agranulocytosis, characterised by a drop in neutrophil count. Theoretically, toxicity may be accounted for by direct action of parent drug or one of its stable metabolites on bone marrow stroma given importance of these cells to neutrophil maturation. Effects of clozapine, N-desmethylclozapine and clozapine N-oxide on … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 7,111 accessesView PDFCite
Research ArticleOpen accessIn the abstractDynamic Kinematics of the Plan Balanced Chain at the Planar Module 3RRelly Victoria Petrescu, Raffaella Aversa, Antonio Apicella, Florian Ion Tiberiu PetrescuAnthropomorphic robots are, as I have already said, in most of the most widespread and widely used works worldwide today, due to their ability to adapt quickly to forced work, working without breaks or breaks 24 h a day, without unpaid leave without asking for food, water, air, or salary. Anthropomorphic robots are supple, elegant, easy to configure and adapted … …Journal of Mechatronics and Robotics, Vol. 2, Issue 1 · 8 Mar 2018 · 6,948 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Inverse Kinematics of the Plane System 2-3 in a Mechatronic MP2R System, by a Trigonometric MethodRelly Victoria Virgil Petrescu, Raffaella Aversa, Antonio Apicella et al.Robots have penetrated today in almost all industrial fields, being much more precise than humans in the execution of operations, but also faster, more dynamic, more stable and more resilient, working 24 h of the 24 h possible, in any season, breaks, holidays, vacations and especially without getting sick. The most important fact is that they can also perform special … …Journal of Mechatronics and Robotics, Vol. 1, Issue 2 · 20 Dec 2017 · 7,813 accessesView PDFCite
Research ArticleOpen accessIn the abstractDirect Geometry and Cinematic to the MP-3R SystemsRelly Victoria Petrescu, Raffaella Aversa, Bilal Akash et al.Mechatronic robotic systems are today widely used worldwide to ease human work, but especially where work is dangerous, in toxic, radioactive, chemical, explosive atmospheres, without air such as underwater or in the cosmos, or in places hard to reach the man. Robots can take the tedious repetitive work under any circumstances and they can perform a difficult operation for a … …Journal of Mechatronics and Robotics, Vol. 1, Issue 1 · 23 Nov 2017 · 7,515 accessesView PDFCite
Research ArticleOpen accessIn the abstractRisk Assessment of Heavy Metals in Fish in Saudi ArabiaOthman M. HakamiHeavy metals such as arsenic, cadmium, mercury and lead constitute a serious threat to human health. Generally, regular consumption of fish is recommended because it is a good source of omega-3 fatty acids, which have been associated with health benefits. However, flesh of some fish species contains heavy metals in high concentration, which may pose health risk for individuals that … …American Journal of Environmental Sciences, Vol. 12, Issue 6 · 3 Dec 2016 · 8,705 accessesView PDFCite
Research ArticleOpen accessIn the abstractApoptosis Inducer Capacity of Cardiotonic Steroids of Urginea maritima Extract on SH-SY5Y Neuroblastoma Cells, with Less Susceptibility among Neuron-Module CellsMaati M. Elghuol, Khalilah Abdul Khalil, Mazatulikhma Mat Zain, Mohamed Saifulaman Mohamed SaidNatural products have played a significant role in conventional treatment and in the development of new drugs for a wide range of illnesses, including malignant disease. Urginea maritima is classified as an herb is endemic to the Mediterranean area. This herb was renowned in traditional ethnopharmacological applications. Notwithstanding, there is a lack of evidence pertaining to the characterization of the … …American Journal of Applied Sciences, Vol. 13, Issue 5 · 28 May 2016 · 7,352 accessesView PDFCite
Research ArticleOpen accessIn the abstractTowards the Efficiency of Municipal Solid Waste Management in the Democratic Republic of Congo (DRC): Case Study of LubumbashiMartin T. Mpinda, Olusegun K. Abass, Mujinya B. Bazirake et al.This paper provides an overview on the state of Municipal Solid Waste Management (MSWM) in Lubumbashi, D.R Congo. To meet the recently proposed Sustainable Development Goals (SDGs), establishment of efficient waste management techniques and strategies geared towards monetizing waste in the framework of sustainable growth is inevitable. Solid waste categorization and collection in conjunction with recycle, reuse and revalue are … …American Journal of Environmental Sciences, Vol. 12, Issue 3 · 27 May 2016 · 10,157 accessesView PDFCite
Research ArticleOpen accessIn the abstractChemical Mutagenesis for Improvement of Production of a Biologically Active Extracellular Polymeric Substance by Halomonas xianhensis SUR308Jhuma Biswas, Amal K. PaulA moderately halophilic bacterium, Halomonas xianhensis SUR308 (Genbank Accession No. KJ933394) isolated from solar saltern of Surala, Odisha, India was found to produce significant amount of a biologically active extracellular polymeric substances (EPS). Under optimized cultural conditions, the strain was able to produce 7.05 g L-1 of EPS after 8 days of incubation under shake culture. To enhance the EPS … …Current Research in Microbiology, Vol. 7, Issue 1 · 1 Apr 2016 · 15,926 accessesView PDFCite
Research ArticleOpen accessIn the abstractHippocampal Pyramidal Cell Degeneration and Changes in Creb Protein in Datura stramonium Treated RatsPeter Etim Ekanem, Dare S. Sunday, Sunday Abba, Amanuel TesfayDatura Stramonium (DS) is a tropical shrub which is available worldwide. It has various uses and is often used to increase the intoxication of certain beverages. The seeds of this plant are very toxic but are commonly smoked in like manner as tobacco. The present study investigated the potential harmful effects of DS on pyramidal cells and CREB protein in … …Neuroscience International, Vol. 6, Issue 2 · 17 Sep 2015 · 7,066 accessesView PDFCite
Review ArticleOpen accessIn the abstractSelected Genotoxic Impurities Profiling During WFI Qualification to Control Carcinogenesis in Large Volume ParenteralsMohabbat UllahWater For Injections (WFI) which is the main vehicle of Large Volume Parenterals (LVPs) should be free from trace amount of genotoxic impurities. This review gives emphasis on quantification of genotoxic trace metals during qualification of WFI in LVPs manufacturing unit. According to ICH guidelines, impurities related to drug substances are classified into three main categories: Organic impurities, inorganic (elemental) … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 27 May 2015 · 7,710 accessesView PDFCite