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Research ArticleOpen accessIn the author namesThe Hypoxia-Inducible Factor-1Î± Signaling Pathway and its Relation to Cancer and ImmunologyBruno R.B. Pires, Andre L. Mencalha, Gerson M. Ferreira et al.Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor that is present in all metazoans from early embryonic development throughout adult life. It plays a major roles in the different stress responses that are triggered by low Oxygen (O2) levels and its expression is associated with cell survival. HIF-1 is a heterodimer protein that comprises the subunits HIF-1Î± and HIF-1Î². The … …American Journal of Immunology, Vol. 10, Issue 4 · 17 Jan 2015 · 8,485 accessesView PDF Cite

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