Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice
Ahmed Flayyih Hasan1, Azhar Azher Alankooshi2,3, Alaa Saadi Abbood1, Ali Ghazi Dulimi4, Hiba Mohammed Al-Khuzaay5, Eslam Ahmed Elsaedy6 & Ehab Tousson3 Show affiliations
- Department of Biology, Al-Farabi University College, Baghdad, Iraq
- Department of Human Physiology, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Iraq
- Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
- Department of Human Dentistry, Bilad Alrafidain University College, Diyala, Iraq
- Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
- Department of Biochemistry, Faculty of Medicine, Alexandria University, Tanta, Egypt
OnLine Journal of Biological Sciences, Volume 23, Issue 1, pp. 103–108 · doi.org/10.3844/ojbsci.2023.103.108
Abstract
Several studies have been focused on identifying alternative medicines for the treatment of cancer. This study aimed to investigate the impact of B-Glucans extract (BG) against Ehrlich Ascites Carcinoma (EAC) induced toxicity and tissue damage in kidney. A total of 40 mice were assigned randomly to four groups (G1, control; G2, B-Glucans (75 mg/kg bw/day) orally for 2 weeks; G3, EAC and G4, EAC + BG). Current results revealed, EAC induced significant elevation in urea, creatinine, potassium (k+), chloride (Cl-) ions, kidney injury and significant decrease in sodium (Na+) and calcium (Ca++) ions when compared to B-glucans and control groups. Conversely, EAC + B-glucans modulate these changes and improved the renal functions and structure. EAC induced renal dysfunction and B-Glucans has the ability to improve renal functions. We can conclude that; BG could be used as an adjuvant therapy for kidney in ascites of hepatocellular carcinoma, Schistosoma and hepatitis.
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Hasan, A. F., Alankooshi, A. A., Abbood, A. S., Dulimi, A. G., Mohammed Al-Khuzaay, H., Elsaedy, E. A. & Tousson, E. (2023). Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice. OnLine Journal of Biological Sciences, 23(1), 103–108. https://doi.org/10.3844/ojbsci.2023.103.108
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