Application of Human Adipose Stem Cell (hADSC) in Collagen Gel on Rat Deep Dermal Burn
Helsy Junaidi1, Puji Sari2, Dwi Pratami Septiara1, Jeanne A. Pawitan3 & Luluk Yunaini2 Show affiliations
- Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia
- Departemen of Biology of Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia
- Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia
OnLine Journal of Biological Sciences, Volume 19, Issue 3, pp. 192–202 · doi.org/10.3844/ojbsci.2019.192.202
Abstract
Human adipose derived stem cells (hADSC) is expected to be an efficient solution for healing deep-dermal burns that help in wound closure. This study used 20 male Sprague dawley rats. Each rat received three wounds with different treatments (control, hADSC in collagen gel and collagen gel). Wound closure was observed at day 7th, 14th, 21th and 28th (sacrificed day) macroscopically, wound areas were measured and collagen densities were evaluated. Reduction of wound area showed significant difference between hADSC in collagen gel group and control group (p 0.001) and between hADSC in collagen gel group and collagen gel group. The hADSC in collagen gel group had a higher collagen density compared to control and collagen gel group. Application of hADSC in bovine collagen gel in rat deep-dermal burn models provided faster and better wound healing compared with control and bovine collagen gel group.
Licence and reuse
Open access. This article is licensed under a Creative Commons Attribution 3.0 Licence (CC BY 3.0), as printed on the article, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original authors and the source. No permission is needed.
How to reuse this articleResponses (0)
About this article
Junaidi, H., Sari, P., Septiara, D. P., Pawitan, J. A. & Yunaini, L. (2019). Application of Human Adipose Stem Cell (hADSC) in Collagen Gel on Rat Deep Dermal Burn. OnLine Journal of Biological Sciences, 19(3), 192–202. https://doi.org/10.3844/ojbsci.2019.192.202
- Licence
- CC BY 3.0
- Issue
- Volume 19, Issue 3
- Policies
- Editorial independenceUse of generative AIData availabilityAppeals and complaints
- Version
- Version of record