Research ArticleOpen accessIn the keywordsThe Functional Effect of Kaempferia Parviflora on Ischemic Stroke in RatsWathita Phachonpai, Sinthuporn Maharun, Terdthai Tong-Un et al.Problem statement: Oxidative stress has been implicated as important factors in the pathogenesis of cerebral ischemia-induced behavioral deficits particularly memory. Growing attention is being paid to traditional medicinal plants possessing antioxidant activity, as they have been proved therapeutically/prophylactically fruitful against stroke condition. Present study provides evidence of the neroprotective effects of a Thai traditional herb, Kaempferia Parviflora (KP) extract, against … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 2 · 16 Mar 2012 · 8,742 accessesView PDFCite
Research ArticleOpen accessIn the abstractFerulic Acid in Chinese Herbal Medicine: Regulating Autophagy for Oxidative Damage ReductionZhiyuan Lv, Qiaozhen Zhao, Shanbin Chen et al.Ferulic Acid (FA) is the primary functional component in herbal plants and traditional fermented foods. To comprehend the mechanism of action of ferulic acid, in terms of its regulation of autophagy, antioxidants and the inhibition of inflammatory pathways, the study was conducted. Oxidatively damaged human-derived hepatocytes were treated with FA and the processing concentration of FA is from 50-800 μm. … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 1 Jun 2024 · 5,486 accessesView PDFCite
Review ArticleOpen accessIn the abstractAntihypertensive Effects of Brazilian FruitsAugusto Altoé Puppin, Christiane Mileib Vasconcelos, Mirian de Almeida Silva et al.Cardiovascular disease is a health problem that generates economic and social impacts worldwide and hypertension is a major risk factor for the development of cardiovascular disease. Currently, conventional medicine offers treatments that control and regulate blood pressure through medication, but the traditional medicines of different cultures have used plants and foods to treat and prevent this type of disease for … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 19 Jun 2020 · 7,192 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico Analysis of three Committed-Steps Involved in Triterpenoid Biosynthesis from Ganoderma lucidumXiaorong Shui, Xiaozhong Lan, Wei LeiGanoderma lucidum is widely considered as one of the most valuable Traditional Chinese Medicines, with various bioactive constituents and pharmaceutical effects. Triterpenoids are important effective ingredients of G. lucidum, which are synthesized mainly through the mevalonate pathway. In this study, we aimed to characterize and analyze three committed-step enzymes of the mevalonate pathway, 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMGR), Farnesyl Diphosphate Synthase … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 15 Aug 2016 · 7,349 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,164 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of Quantitative Plant Activity Relationship (QPAR) for Diabetics II Using Genetic AlgorithmSimanta Kumar Nayak, Bikram Kesari Ratha, Payodhar Padhi et al.The present study demonstrates a novel computational approach for Indian Traditional Medicine (ITM) for the effective antidiabetic drug. Indian traditional practitioners are using many natural Herbals for the cure of diabetes. Though many diabetes patients are getting temporarily cured still its cause and effects are unknown due to lack of proper scientific investigation. Individual plant bioactivities have been already investigated … …Journal of Computer Science, Vol. 11, Issue 3 · 1 Apr 2015 · 6,715 accessesView PDFCite
EditorialOpen accessIn the abstractANTIBIOTIC RESISTANCE: A FRIGHTENING HEALTH DILEMMARuchi Tiwari, Kuldeep DhamaByarugaba, D.K., 2004. Antimicrobial resistance in developing countries and responsible risk factors. Int. J. Antimicrob. Agents, 24: 105-110. DOI: 10.1016/j.ijantimicag.2004.02.015 Cirz, R.T., J.K. Chin, D.R. Andes, V. de Crécy-Lagard and W.A. Craig et al., 2005. Inhibition of mutation and combating the evolution of antibiotic resistance. PLoS Biol., 3: e176-e176. DOI: 10.1371/journal.pbio.0030176 Dhama, K., S. Chakraborty, Mahima, M.Y. Wani and A.K. … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 3 · 26 Sep 2014 · 10,778 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnticancer Activity of Isolated Chemical Constituents from Miliusa smithiaeChonthicha Naphong, Wilart Pompimon, Punchavee SombutsiriMiliusa plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. There have been a few previously reports on the chemical constituents of plants in this genus, describing the presence of aporphine alkaloids, terpenoids, flavonoids, phenylpropanoids, styrylpyrones, bis-styryls and homogentisic acid derivatives. Miliusa smithiae, a new species for Thailand and world, has … …American Journal of Applied Sciences, Vol. 10, Issue 8 · 24 Jul 2013 · 7,263 accessesView PDFCite