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228 articles for “toxicity”
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Research ArticleOpen accessEvery word in the titleEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,241 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleToxicity of Dinoflagellate (Gonyaulax verior) from Makassar Strait Waters on Medaka Fish (Oryzias javanicus) Embryo DevelopmentNita Rukminasari, Khusnul Yaqin, Jamaluddin Fitrah AlamThis study investigates the toxic effects of the dinoflagellate Gonyaulax verior on the embryonic development of medaka fish (Oryzias javanicus) sourced from four distinct aquatic environments in the Makassar Strait. Given the increasing presence of harmful algal blooms in marine ecosystems, understanding the impact of toxic dinoflagellates is crucial for assessing risks to fish populations. Embryos were exposed to varying … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 20 Nov 2025 · 2,123 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOptic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial ToxicityConnor Dyer, Katlyn Droke, Ugne Zekonyte, Mariana RoscaDeleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 19 Jan 2024 · 8,562 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOrlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female RatsHaneen Mushtaq Hameed, Ahmed Flayyih Hasan, Zainab Haytham Razooki et al.Obesity has been linked to several chronic diseases, including fatty liver disease, fatty heart disease, diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was to determine how Orlistat affected renal toxicity, DNA damage, and apoptosis that were brought on by obesity in normal and obese female rats. There were four groups made up of … …OnLine Journal of Biological Sciences, Vol. 23, Issue 1 · 18 Jan 2023 · 5,831 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProtective Effect of Curcumin Against Hepatic Toxicity Induced by Lithium Carbonate (Li2 Co3)Gehan B.A. Youssef, Ahlam F. Hamoda, Rabab R. Elzoghby et al.The current work was done on four groups of rats (10 for each) to detect the hepato-protective characters of curcumin on the toxicity induced by lithium carbonate. The oral administration of Li2 Co3 for one-month lead to noticeable decrease in the SOD, CAT and GSH while the increase in the GPx and some histological changes in the portal tissues including … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 31 Jul 2019 · 7,603 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Characterization of Bacillus thuringiensis from soil habitat of Auky Island, Padaido District in Biak Numfor Regency and Its Toxicity against Mosquito Larva of Anopheles spLantang Daniel, Rampa Ester, Lunga NellyBacillus thuringiensis (Bt) is bacteria that produce protein crystals as an insecticidal against various vector diseases in plants and animals including humans. The purpose of this research is to discover the local isolate toxicity of B. thuringiensis from Auky Island Padaido District in Biak Numfor Regency against mosquito larva Anopheles sp., as well as to discover the local isolate of … …American Journal of Infectious Diseases, Vol. 14, Issue 2 · 4 Sep 2018 · 9,147 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDifferential Gene Transcription in Red Oak (Quercus rubra) Genotypes Resistant to Copper ToxicityProulx Migueal, Paul Michael, Charnelle Djeukam, Kabwe NkongoloToxicity of metals is a major abiotic stressor of plants. Copper (Cu) is one of the most abundant metals in soils from the Greater Sudbury Region (GSR) due to its mining history. Recent studies have described several transporters and chelating proteins involved in copper resistance. Quercus rubra (Red Oak) is a common species that grows in metal contaminated soils in … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 11 Dec 2017 · 8,545 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAmeliorative Impacts of Tribulus terrestris Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological StudySally I. Ismaiel, Sameh M. Farouk, Raafat A. El-Ramady, Waleed F. KhalilThe current work aimed to investigate the protective effects of Tribulus terrestris extracts against ivermectin-induced hepatic and renal toxicity in male rabbit. Selenium plus vitamin E was used as a comparative standard drug to evaluate the efficacy of Tribulus terrestris extract on some hematological parameters, kidney and liver enzymes as well as associated histopathological changes. This work was carried out … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 12 Jan 2017 · 7,766 accessesView PDFCite