5 articles for “retinoids”

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Research ArticleOpen accessEvery word in the titleRetinoids Chemosensitize Ovarian Cancer Cell Lines to Cisplatin Independent of Nuclear Receptors and p53Suresh Guruswamy, Doris M. BenbrookTreatment of ovarian cancer with cisplatin-based chemotherapy is highly toxic and is often followed by cancer recurrence. Repeated treatments with cisplatin frequently result in the development of resistance to this drug. Drugs with low toxicity that could enhance the tumor cell killing effects of cisplatin could potentially reduce the toxicity and enhance the efficacy of cisplatin. The mechanism of cell … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,958 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,477 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleRetinoids and Opioids: Factors in the Development of HIV-Related Neurological DiseaseWalter Royal, III, Joseph L. BryantNeurological disease occurs frequently in HIV-infected individuals and may occur at even higher rates among infected drug users. Among the potential mechanisms that promote such impairment, retinoid deficiency may have selective effects that could both lead to alterations in immune function and enhanced replication of HIV. Studies are currently underway to examine the possible selective effects of retinoid receptor activation … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,764 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsBioconversion Efficiency of β-Carotene from Mango Fruit and Carrots in Vitamin AJose de Jesus Ornelas-Paz, Elhadi M. Yahia, Alfonso A. Gardea-BejarProblem statement: Bioconversion efficiency of β-Carotene (BC) in vitamin A is strongly influenced by food matrix. This efficiency has been determined mainly in typical BC sources like carrots. BC content in mango fruit is considerably high however; the bioconversion efficiency of BC from fresh mango in vitamin A has not been determined nor compared with those of typical BC sources. … …American Journal of Agricultural and Biological Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,428 accessesView PDF Cite

Research ArticleOpen accessIn the abstractATRA AS A POTENTIAL ANTIMETASTATIC AGENT IN COLORECTAL ADENOCARCINOMARobert Edwards, Kambiz Afrasiabi, Kehui WangThe family of Retinoic acid compounds have long been the subject of intense study and interest as chemo prophylactic agents. This dates back to their therapeutic effect in leukoplakia Where ATRA was shown to lead to the reversal of premalignant lesions and Subsequent reports on their use in metastatic colorectal adenocarcinoma and a vast array of other malignant disorders as … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 26 Mar 2014 · 7,344 accessesView PDF Cite