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66 articles for “oxidative damage”
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Research ArticleOpen accessPhrase in the titleAntioxidant Activity of Trilobatin and Its Inhibitory Effects on Oxidative Damage of Biological MacromoleculesYuhan Zhai, Yuqing Zhang, Yaping Li et al.Excessive levels of free radicals in the body cause oxidative damage to macromolecules by injuring DNA, proteins, and lipids, which leads to structural and functional defects and ultimately results in a number of illnesses. The antioxidation of trilobatin and its inhibitory activity of trilobatin on oxidative damage of biological macromolecules have not been thoroughly investigated. In this research, the effects … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 28 Oct 2023 · 5,466 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleInhibitory Effect of Crude Walnut Leaf Polysaccharides on Oxidative Damage of Proteins and Proliferation of SGC-7901 CellsShuqing Yang, Zhike Xie, Shuyan Yu et al.In this paper, we studied the inhibitory effect of crude Walnut Leaf Polysaccharides (WLP) on free radical-induced oxidative damage of proteins and anti-proliferation activity on human Gastric Cancer cells (SGC-7901). The oxidative degradation of Bovine Serum Albumin (BSA), mouse brain proteins (MBP) and Mouse Liver Proteins (MLP) induced by hydroxyl radical and alcoxyl radical was analyzed by Sodium Dodecyl Sulfate-Polyacrylamide … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 26 Apr 2020 · 7,057 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleMoringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral IschemiaWoranan Kirisattayakul, Jintanaporn Wattanathorn, Terdthai Tong-Un et al.Problem statement: At present, the therapeutic outcome of cerebral ischemia is still not in the satisfaction level. Therefore, the preventive strategy is considered. Based on the protective effect against oxidative damage of Moringa oleifera Lam. Leaves extract, we hypothesized that this plant extract might protect against cerebral ischemia, one of the challenge problems nowadays. In order to test this hypothesis, … …American Journal of Applied Sciences, Vol. 9, Issue 9 · 3 Aug 2012 · 7,574 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleFerulic Acid in Chinese Herbal Medicine: Regulating Autophagy for Oxidative Damage ReductionZhiyuan Lv, Qiaozhen Zhao, Shanbin Chen et al.Ferulic Acid (FA) is the primary functional component in herbal plants and traditional fermented foods. To comprehend the mechanism of action of ferulic acid, in terms of its regulation of autophagy, antioxidants and the inhibition of inflammatory pathways, the study was conducted. Oxidatively damaged human-derived hepatocytes were treated with FA and the processing concentration of FA is from 50-800 μm. … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 1 Jun 2024 · 5,483 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleGreen Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in RatsMauren Assis Souza, Caroline Dalla Colletta Altermann, Alexandre dos Santos Martins et al.The present study shows the neuroprotective effect of green tea supplementation (GT; Camellia sinensis) in a model of Intracerebral Hemorrhage (ICH) in rats. ICH was induced by intra-striatum collagenase infusion in male Wistar rats. GT (400 mg Kg-1) was administered via gavage for 10 days after ICH. We assessed the effect of GT on neuromotor recovery and oxidative damage. Our … …Neuroscience International, Vol. 7, Issue 2 · 19 Mar 2017 · 8,598 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe Ovario-Protective Effect of Erythropoietin against Oxidative Damage Associated with Reperfusion Following Ovarian Torsion in RatSayyah-Melli Manizheh, Kazemi-Shishvan Maryamalsadat, Solaimani-Rad Jafar et al.Problem statement: To show the effect of recombinant Erythropoietin (rhEPO) on the ovarian viability and histology in the twisted ischemic ovaries in rats, followed by detorsion. Approach: An experimental study was conducted in primate clinic of the School of Medicine, Tabriz University of Medical Sciences from Dec. 2008 to Apr. 2009. Forty, 4 month old Wistar rats are cased in … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 1 · 26 Apr 2011 · 7,846 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffects of Flaxseed Supplementation on Lipid Metabolism, Oxidative Balance and Genetic Damage in GoatsMaria Eugenia Cecchini, Dardo Roma, Franco Magnago et al.Epidemiological evidence indicates that flaxseed reduces oxidative stress and cholesterol levels in blood. In this study we evaluated the lipid profile, oxidation of plasma lipids and genetic damage in goats fed on a diet supplemented with flaxseed. Thirteen adult male goats were split in two experimental groups; one of them was fed on a conventional diet of alfalfa and ground … …American Journal of Animal and Veterinary Sciences, Vol. 13, Issue 2 · 22 May 2018 · 7,657 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBiomarkers of Oxidative DNA Damage and Soluble Fas/Fas Ligand in Type 2 Diabetic PatientsMohamed H. Mahfouz, Ibrahim A. Emara, Ghada A. OmarProblem statement: Involvement of oxidative stress in the pathogenesis of diabetic complications has been proposed. 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. Apoptosis via Fas/Fas Ligand (FasL) interactions has been proposed to be a major T-cell-mediated effector mechanism in autoimmune diabetes. This study was undertaken to investigate whether … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 3 Feb 2012 · 7,106 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOxidative Stress and Reproductive Damage Induced by Lead Acetate in Female Guinea Pig (Cavia porcellus): Curative Effects of Hydroethanolic Extract of Spirulina platensisDeutcheu Nienga Sorelle, Ngoula Ferdinand, Manfo Tsague Faustin Pascal et al.This study was aimed at evaluating the curative effects of Hydroethanolic Extract Of Spirulina platensis (HESP) on the reproductive function of female Guinea pig exposed to oxidative stress. Sixty females, 3-4 months old, weighing 300-400 g were divided into six groups (10 animals/group). The neutral control received distilled water, the negative control was treated with lead acetate at a dose … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 1 · 8 Apr 2019 · 7,422 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIn-Vivo Evaluation of Hexavalent Chromium Induced DNA Damage by Alkaline Comet Assay and Oxidative Stress in Catla catlaKantha Deivi Arunachalam, Sathesh Kumar Annamalai, Jaya Krishna KuruvaIn the present study, the acute toxicity of Chromium in fingerlings of Catla catla, an Indian major carp, was evaluated with renewal bioassay method. In vivo studies were designed to assess the extent of Micronucleus Assay, Comet Assay under the exposure of common heavy-metal compounds, namely, Chromium Nitrate, using Catla catla (2n = 20), as a test model. The laboratory … …American Journal of Environmental Sciences, Vol. 9, Issue 6 · 15 Jan 2014 · 7,196 accessesView PDFCite