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26 articles for “neuroprotective”
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Research ArticleOpen accessEvery word in the titleNeuroprotective Effect against Alzheimer's Disease of Porcine Brain ExtractWipawee Thukham-Mee, Jintanaporn Wattanathorn, Supaporn Muchimapura, Chuleratana BunchonglikitkulProblem statement: Despite the increasing importance of Alzheimer’s disease, no effective therapeutic strategy is available. Therefore, neuroprotective strategy is still required. Recent findings show that numerous substances possessing antioxidant can improve neurodegeneration and memory impairment. Based on the antioxidant effect and its reputation to serve as brain tonic in traditional folklore, we hypothesized that porcine brain extract could mitigate neurodegeneration … …American Journal of Applied Sciences, Vol. 9, Issue 5 · 5 Mar 2012 · 8,243 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNeuroprotective Effect against Cerebral Ischemia of Passiflora foetidaJintanaporn Wattanathorn, Natcha Sattroopinat, Terdthai Tong-Un et al.Problem statement: Although cerebral ischemia induced by stroke has been regarded as the important problem worldwide, the therapeutic efficacy is still inadequate. Since the free radicals are implicated in the pathophysiology of cerebral ischemia, the prophylactic protection against stroke with neuroprotective agent possessing antioxidant effect has gained much attention. Therefore, this study was designed to determine whether the alcoholic extract … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 16 Feb 2012 · 8,242 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNeuroprotective Effect of Quercetin Encapsulated Liposomes: A Novel Therapeutic Strategy against Alzheimer’s DiseaseW. Phachonpai, J. Wattanathorn, S. Muchimapura et al.Problem statement: The prevalence of Alzheimer’s disease is increasing but the efficacy of treatment is still very limited due to various factors including the blood brain barrier. Recent findings demonstrated the crucial role of oxidative stress on the pathophysiology of disease. In addition the burden of blood brain barrier can be overcome by nasal administration and vesicle-carrier mediated delivery system. … …American Journal of Applied Sciences, Vol. 7, Issue 4 · 30 Apr 2010 · 9,449 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImmunohistochemical Detection of Apoptosis-Related Proteins in Gerbil Hippocampus Transient Cerebral Ischemia: Neuroprotective Effect of PitavastatinToshiki Himeda, Natsumi Hayakawa, Hiroko Tounai et al.Delayed and selective neuronal damage was caused in the CA1 sector of hippocampus following 5 min of transient cerebral ischemia in gerbils. We investigated the immunohistochemical alterations of apoptosis-related proteins such as bcl-2α, bcl-xs/l, bax, cytochrome c, and active caspase 3 and TUNEL staining in the hippocampus at 1 and 5 hr and 1, 2, 5 and 14 days after … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,271 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAnti-Stress Effects of Kaempferia parviflora in Immobilization Subjected RatsJintanaporn Wattanathorn, Terdthai Tong-un, Supaporn Muchimapura et al.It is well known that intense and prolonged stress can produce hippocampal neuronal damage and cognitive impairments, few studies have investigated possible ways to prevent its deleterious effects. Here, we investigated the neuroprotective effects of a Thai traditional herb, Kaempferia Parviflora (KP) extract, commonly known as Kra-Chai-Dum, on learning and memory loss and the induction of neurodegeneration in the hippocampus … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 14 May 2013 · 8,677 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCoscinium Fenestratum Protects Against Ethanol-Induced Neurodegeneration in Adult Rat BrainWathita Phachonpai, Jintanaporn Wattanathorn, Panakaporn Wannanon et al.Alcoholism is a serious problem throughout the world. Despite intensive efforts to develop novel therapeutics for strategy efficacy against neuronal loss leading to memory impairment in alcoholism is still limited. In view of the pitfalls of psychological dependence and adverse behavioral effects of synthetic drugs, the development of low toxicity and high efficiency medicines derived from natural herbal antioxidants exhibits … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 16 Aug 2012 · 8,602 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMoringa Oleifera Lam Mitigates Oxidative Damage and Brain Infarct Volume in Focal Cerebral IschemiaWoranan Kirisattayakul, Jintanaporn Wattanathorn, Terdthai Tong-Un et al.Problem statement: At present, the therapeutic outcome of cerebral ischemia is still not in the satisfaction level. Therefore, the preventive strategy is considered. Based on the protective effect against oxidative damage of Moringa oleifera Lam. Leaves extract, we hypothesized that this plant extract might protect against cerebral ischemia, one of the challenge problems nowadays. In order to test this hypothesis, … …American Journal of Applied Sciences, Vol. 9, Issue 9 · 3 Aug 2012 · 7,574 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEffect of Dietary Kaempferia parviflora on Ischemic Brain Injury in the ratWathita Phachonpai, Sinthuporn Maharun, Supaporn Muchimapura et al.Problem statement: Stroke often causes irreversible neuronal damage and related behavioral deficits. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional plant medicines. We investigated the ability of consuming Kaempferia parviflora extract, a Thai medicinal plant reputed for neuroprotective effects against brain damage, reduced infarct volume and improve neurological … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 20 Mar 2012 · 9,088 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Role of Ganoderma lucidum Polysaccharides Against Stress Induced by Heavy Metals in Caenorhabditis elegansHuixiu Ma, Dehui Dai, Guicai Chen, Weilian HuAli, H., Khan, E., & Ilahi, I. (2019). Environmental Chemistry and Ecotoxicology of Hazardous Heavy Metals: Environmental Persistence, Toxicity, and Bioaccumulation. Journal of Chemistry, 2019, 6730305. https://doi.org/10.1155/2019/6730305 Aljerf, L., & Aljerf, N. (2023). Food products quality and nutrition in relation to public. Balancing health and disease. Progress in Nutrition, 25(1), e2023024. https://doi.org/10.23751/pn.v25i1.13928 Aljerf, L., Williams, M., Ajong, A. B., Onydinma, … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 18 May 2024 · 6,947 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Extracts of Bay Leaf (Laurus nobilis) and Rosemary (Rosmarinus officinalis) Inhibit Iron-Induced Lipid Peroxidation and Key-Enzymes Implicated in Alzheimer’s Disease in Rat Brain-in VitroAyodeji O. Falade, Goodness I. Omolaiye, Kayode E. Adewole et al.Neurological disorders remain a global health challenge, with Alzheimer’s Disease (AD) as the most famous cause of dementia in old people. Nevertheless, culinary spices and herbs have shown promising potentials in the management of neurological diseases. This study aimed at investigating the neuroprotective property of aqueous extracts of bay leaf (Laurus nobilis) and rosemary (Rosmarinus officinalis) by assessing the antioxidant … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 1 · 25 Jan 2022 · 7,955 accessesView PDFCite