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13 articles for “morphine”
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Research ArticleOpen accessEvery word in the titleThe Intracerebroventricular Administration of W-7, A Calmodulin Inhibitor, Attenuate the Development of Morphine Tolerance in RatsGholamreza Sepehri, Vahid Sheibani, Afrooz Azarang et al.Problem statement: The present study was performed to determine the effect of Intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the analgesic effect and development of tolerance to antinociceptive effect of acute and chronic morphine administration respectively. Approach: This study was carried out on male wistar rats, weighing 200-250 g. For acute experimental protocol, Morphine was injected intraperitonealy … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,752 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effects of W7, a Specific Calmodulin Inhibitor, to the Antinociceptive Effects of Morphine in Adrenalectomized RatsGholamreza Sepehri, Kayvan Yaghoobi, Vahid Sheibani et al.Problem statement: This study was performed to evaluate the effect of W7 (specific calmodulin inhibitor) on morphine induced analgesia in Adrenalectomized (ADX) rats by tail-flick test. Approach: Tolerance to morphine was induced in male Wistar rats by daily injections of morphine (15 mg kg-1, i.p) for 8 days. Adrenalectomy was performed under general anesthesia with intraperitoneal (i.p) injection of ketamine … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,649 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Short Time Morphine Addiction on the Kidney Tissue in RatReza Malekpourafshar, Hamid ZeinalinejadOpium is an important substance that abuses and has very pharmacological and pathological effects. Morphine is the main substance of opium. In the recent study, it has been tried to identify the short effects of morphine on the kidney pathology of Rats. The randomized double blind study was designed. Twenty rats were selected and divided in two groups and maintained … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,397 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,937 accessesView PDFCite
Research ArticleOpen accessIn the keywordsNeuropharmacological Assessment of an Aqueous Bark Extract of Antiaris toxicaria (Pers.) Lesch. (Moraceae) in RodentsPriscilla K. Mante, Donatus W. Adongo, Kennedy K.E. Kukuia et al.Antiaris toxicaria is a plant traditionally used in Ghana for the treatment of various neurological conditions such as epilepsy and pain. This present study therefore seeks to screen for the neuropharmacological activities of the aqueous extract of Antiaris toxicaria (AAE) stem bark. The effect of Antiaris extract on pentobarbital-induced sleeping time, tail immersion test, spontaneous locomotor activity, motor coordination, PTZ-induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 4 · 27 Nov 2012 · 7,794 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRole of HIV-1 Infection in Addictive Behavior: A Study of a HIV-1 Transgenic Rat ModelSulie L. Chang, Michael VigoritoEpidemiological research indicates that drug abuse is prevalent among individuals infected with HIV-1. Evidence from preclinical research also suggests that drugs of abuse exacerbate the progression of neuropathological changes in the HIV-1 infected brain probably through common mechanisms of neuronal injury. The effects of HIV-1 on the efficacy and abuse potential of controlled drugs such as morphine, however, has not … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,630 accessesView PDFCite
EditorialOpen accessIn the abstractNaloxone as a Harm Reduction Initiative: Misinterpretations of ResearchRichard R. MassattiIn the American Medical Journal, Annahita Beheshti and colleagues review the literature on naloxone use for opioid overdose in West Virginia (Beheshti et al., 2015). The authors cite several of my publications in support of their views on naloxone (Massatti, 2013; Massatti et al., 2014), but many of these citations misinterpret my work by using it to present a counterargument … …Current Research in Medicine, Vol. 7, Issue 1 · 9 Apr 2016 · 8,029 accessesView PDFCite
Research ArticleOpen accessIn the abstractTotal Synthesis of Endangered Frog Alkaloid ’Epibatidine’, A Potent Analgesic of the FutureN.R. Dhatrak, M.G. Kulkarni’Epibatidine’ is a nicotinic alkaloid’, was first discovered in the skin of neotropical poisonous frog, ’Epipedobates tricolor’ found in Ecuador. John Daly in 1974 first isolated a trace quantity of this alkaloid by scarifying several frogs. With the evolution of NMR techniques the structure of this alkaloid was reported in 1992. An year after, Nobel Laureate Prof. E.J. Corey, devised … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 17,112 accessesView PDFCite
Research ArticleOpen accessIn the abstractForensically Flies Detect the Nutritional Value of Corpses Through Neuro-Chemoreceptive Cells-(5th Cell)Hedayat Abdel Ghaffar, Tarek Tantawi, Ibrahim Gaboub et al.Animals have evolved several chemosensory systems for detecting potentially dangerous foods in the environment. Activation of specific sensory cells within these chemosensory systems usually elicits an aversive behavioral response, leading to avoidance of the noxious foods. Blowflies respond to sugars, salts and water through the activation of specific chemoreceptor neurons in the antennal, labellar and tarsal chemosensillae. These insects also … …Neuroscience International, Vol. 3, Issue 2 · 5 Sep 2012 · 7,243 accessesView PDFCite
Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,871 accessesView PDFCite