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11 articles for “liver histopathology”
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Research ArticleOpen accessIn the keywordsABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATSJ. Asiedu-Gyekye Isaac, Awortwe Charles, A. Antwi DanielAllium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 30 Jan 2014 · 7,578 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental ModelTrivendra Tripathi, Aijaz Ahmed Khan, Mohammad Shahid et al.Problem statement: Since in vivo studies looking for toxicological impact of histamine receptors-agonists in experimental models are fragmentary, the present study was designed to delineate the histopathological and biochemical changes in livers of rabbits treated with histamine receptors (H1R-H4R)-agonists. Approach: The cohort comprised of six groups (Group I control and Group II-VI treated) containing five rabbits each. Control-group received vehicle … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 8,905 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepato and Nephrotoxicity Caused by Sub-Chronic Exposure to Relevant Concentrations of Human Exposure to Glyphosate-Based Herbicide: An Experimental Study in RatsFernanda de Maria Serra, Letícia Rocha Magalhães, Beatriz Bertholace Magalhães Silva et al.Glyphosate's remarkable effectiveness in weed control has made it among the foremost widely employed herbicides globally. Several Glyphosate-Based Herbicides (GBHs) contain 1-4 dioxane, a compound known to induce cancer in animals and potentially contribute to liver and kidney damage in humans. The objective was to assess the liver and kidney toxicity resulting from sub-chronic exposure to GBH in rats. Eighty … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 26 Dec 2023 · 5,198 accessesView PDFCite
Case ReportOpen accessIn the abstractRetroperitoneal Hydatid Cyst Masquerading as a Retroperitoneal Cystic TumorK. Hemanth Kumar, Anish Choudhary, Amaresh Aruni, N.V.K.N. KarthikHydatid disease is an endemic disease, with canines the primary host and humans the intermediate host. Liver, spleen and lungs are most common involved organs, but it can involve any organ. Retroperitoneal hydatid cyst are categorised into two types, primary and secondary. Primary retroperitoneal hydatid cyst is rare disease, with most of the cases diagnosed intra-operatively, hence pre-operative high index … …American Journal of Infectious Diseases, Vol. 15, Issue 3 · 29 Aug 2019 · 7,269 accessesView PDFCite
Research ArticleOpen accessIn the abstractModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,721 accessesView PDFCite
Research ArticleOpen accessIn the abstractPRESUMPTIVE REOVIRUS INFECTION IN BROILER BREEDERSF. A. Moreira, M. L. Pinto, L. Cardoso, A. C. CoelhoTenosynovitis is one of the pathological manifestations of avian reovirus infection and are of economic importance, special in one of the most important stages of the poultry industry, i.e., broiler breeders. In late May 2012, an outbreak of unilateral lameness occurred in a broiler breeder flock (15,000 birds divided by two houses) of a multi-age farm, with a total of … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 1 · 3 Feb 2014 · 7,006 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Effect of N-Acetylcystiene on the Toxic Hazards of titanium Dioxide NanoparticlesHossam Fouad Attia, Mohamed Mohamed Soliman, Gamal Hassan Abdel-Rahman et al.The present study was directed to evaluate the toxic effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats and to evaluate the ameliorative effects of N-acetylcysteine (NAC). Forty adult male albino rats were divided into 4 groups; control group, NAC group, TiO2 group and TiO2/ NAC group. Rats were administered either TiO2 (1200 mg kg-1 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 26 Sep 2013 · 8,139 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Stem Bark Extract of Spathodea campanulata (P. Beauv) Modulates Carbon Tetrachloride Induced Hepatic Damage in RatsCharles Ansah, Phyllis Elsie Dadzeasah, Emmanuel AsiamahThe objective of the present study was to evaluate the hepatoprotective and curative potential of the aqueous extract of the stem bark of Spathodea Campanulata (SCE) in a carbon tetrachloride-induced model of hepatotoxicity in rats. Rats pre-treated with 625 mg kg-1, 1250, 2500 mg kg-1 or silymarin (50 mg kg-1) p.o for 3 days were intoxicated with CCl4 (1 mL … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 27 May 2013 · 9,003 accessesView PDFCite
Research ArticleOpen accessIn the abstractPossible Mechanism of Plumbago zeylanica in Prevention of Hepatic Dammage in Wistar RatRohit Goyal, Pyare Lal SharmaPlumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kg-1, p.o.) or CCl4 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,641 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,245 accessesView PDFCite