4 articles for “folate”

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Research ArticleOpen accessIn the keywordsTotal Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age GroupsFaisal I. Mohammad, Sally Awawdeh, Akram Saleh, Nabil A. BashirProblem statement: Elevated plasma total homocysteine concentration is a risk factor of cardiovascular disease. Total homocysteine level is a strong predictor of mortality in-patient with an angiographically confirmed Coronary Heart Disease (CHD), so we want to know at what age in males and females elevated homocysteine will be significantly elevated and this will help for better management and prognosis by … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,540 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsKinetic Optimization of Folic Acid Polymer Conjugates for Drug TargetingJacob M. Ngoy, Sunny E. Iyuke, Clarence S. Yah, Wilhelm E. NeuseProblem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 7,101 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDesign and Synthesis of Diaminotriazines as Anti-Tuberculosis DHFR InhibitorsArundhati C Lele, Archana Raju, M.K. Ray et al.A series of novel 2,4 diamino-s-triazine was designed as potential Mycobacterium tuberculosis (Mtb) Dihydro folate reductase inhibitors. The synthesized compounds were evaluated in whole cells by employing Resazurin Microtitre Plate Assay (REMA) against Mtb H37Rv, using known DHFR inhibitors Methotrexate and Trimethoprim as standard drugs. The most active compound in the whole cell assay was selected for DHFR enzyme assay … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,716 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRole of Biopterin Transporter (BT1) Gene on Growth and Infectivity of LeishmaniaManju Jain, Vandana S. Dole, Peter J. Myler et al.Leishmania are known to be auxotrophic for pteridines that are known to play a critical role in the parasites survival. In the present work the role of biopterin transporter in the growth of the parasite and infectivity in to macrophages has been worked out. The role of biopterin transporter in the susceptibility of Leishmania to antimonial compounds has also been … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,038 accessesView PDF Cite