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Research ArticleOpen accessIn the keywordsProphylactic Effects of Melatonin on Sodium Valproate-Induced Neural Tube Defects and Skeletal Malformations in Rat EmbryosOmolbanin Rahgazar, Reza Ranjbar, Hossien Najafzadeh Varzi, Mahmood Khaksary MahabadyProblem statement: Some reports showed the teratogenic effects of sodium valproate can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. Therefore, in this study, the prophylactic effect of melatonin on teratogenic effects of sodium valproate was compared. Approach: This study was performed on 31 pregnant rats that were divided into five groups. Control group … …American Journal of Applied Sciences, Vol. 8, Issue 5 · 17 May 2011 · 7,281 accessesView PDFCite