23 articles for “chronic toxicity”

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Research ArticleOpen accessPhrase in the titleAcute and Subchronic Toxicity of Mulberry FruitsJintanaporn Wattanathorn, Wipawee Thukummee, Cholathip Thipkaew et al.At present, the application of phytomedicine worldwide is substantial increase. The data of the acute and subchronic toxicity studies on medicinal plants or fruits and vegetables used for medicinal purposes should be obtained in order to increase the confidence in its safety to human, particularly for the application as functional food. Despite the widely consumption of mulberry (Morus alba L, … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 19 Sep 2012 · 33,868 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titlePhysicochemical Characteristics and Sub Chronic Oral Toxicity of Pistacia lentiscus L. Vegetable Oil in RabbitsMaameri Zineb, Zouhir Djerrou, Sofiane Habibatni et al.Pistacia lentiscus vegetable oil is a well known natural product in Algerian traditional medicine. It is widely used in the treatment of back pain, respiratory problems and skin burns. The aim of this study was the determination of some physicochemical parameters and the investigation of sub-chronic oral toxicity of this fatty oil in rabbits. The physico-chemical parameters obtained for this … …OnLine Journal of Biological Sciences, Vol. 16, Issue 1 · 13 Jan 2016 · 7,466 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleProduction and Characterization of Exopolysaccharide from Novel Bacillus sp. M3 and Evaluation on Development Sub-Chronic Aluminum Toxicity Induced Alzheimer’s Disease in Male RatsMohsen M.S. Asker, Abeer Y. Ibrahim, Manal G. Mahmoud, Saher S. MohamedThe number of patients suffering from Alzheimer’s Disease (AD) all over the world is rising continually and becomes one of the biggest challenges for most societies throughout the world. The potential of peripheral biochemical markers as complementary tools in the neuron-phsychiatric evaluation of these patients has claimed further attention. The aims of our study were to isolate the bacteria that … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 31 May 2015 · 7,216 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleToxicity evaluation of yoyo 'cleanser' bitters and fields Swedish bitters herbal preparations following sub-chronic administration in ratsMartins Ekor, Odusoga Adewale Osonuga, Adesina Olalekan Odewabi et al.Problem statement: Owing to numerous adverse effects of most orthodox pharmaceuticals, the use of herbal remedies in treatment and prevention of diseases is gaining much attention, especially in developing countries. The increase patronage of these remedies is often predicated on the assumption that they are harmless since they are prepared from natural sources. However, toxicity related to herbal medicines is … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 10,198 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsToxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)Diallo Aboudoulatif, Dowou Salem, Badjabaissi Essotolom et al.Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and sub-chronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 16 Mar 2020 · 7,755 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsThe 100-Days Oral Toxicity of Tomato Pomace in Healthy MiceWathita Phachonpai, Supaporn Muchimapura, Jintanaporn Wattanathorn et al.Problem statement: Growing attention is being paid to functional food. The beneficial effect of functional food appears to relate to its bioactive ingredient such as substances containing antioxidant. Therefore, the information about the toxicity of the substances is very much essential to recommend the safety for the substances implication in both clinical and application trials. Herein, we have investigated for … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 23 May 2012 · 7,601 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsA Mathematical Modeling Approach to Characterize Hormesis, Caloric Restriction and Toxicity in Mortality Data from Toxicity StudiesPatricia J. NeafseyThe mortality of a population reflects the combined effects of natural aging with environmental insults (e.g. toxicant exposure, caloric restriction, over feeding, infections, etc.). No single endpoint, such as carcinogenesis, completely describes toxicant-induced effects in laboratory animals. Mathematical models of mortality and time-dependent exposure to toxicants can yield indices of net injury from all causes. With careful manipulation of diet … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,160 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsECOTOXICOLOGICAL BIOASSAYS OF THE EARTHWORMS ALLOLOBOPHORA CALIGINOSA SAVIGNY AND PHERETIMA HAWAYANA ROSA TREATED WITH ARSENATEAbdelmonem Mohamed KhalilLittle research has been carried out on the effect of arsenate on earthworms. Ecotoxicological laboratory tests are fundamental tools for assessing the toxicity of arsenate to soil organisms. In this study, the impact of arsenate on the survival, reproduction and behaviour of the endogenic earthworms Allolobophora caliginosa and the anecic earthworms Pheretima hawayana has been quantified. The 96-h LC 50 … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 27 Sep 2013 · 7,068 accessesView PDF Cite

Research ArticleOpen accessIn the abstractUltrastructural and Circadian Morphometric Characteristics of Rat Pinealocytes Under Physiological and Toxic ConditionsAnna I. Anurkina, David A. Areshidze, Maria A. Kozlova, Valery P. ChernikovCarbon tetrachloride (CCl₄) exhibits pronounced neurotoxic effects following acute or chronic exposure. Recent studies indicate that the pineal gland responds to CCl₄ intoxication by altering its secretory function, although detailed ultrastructural changes in pinealocytes remain inadequately investigated. This research addresses the urgent need to elucidate the mechanisms of CCl₄ toxicity on the pineal gland, which could contribute to developing strategies … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 1 Jun 2026 · 1,170 accessesView PDF Cite

Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDF Cite