Research ArticleOpen accessPhrase in the titleComposite Scaffolds for Bone Tissue EngineeringMin WangBiomaterial and scaffold development underpins the advancement of tissue engineering. Traditional scaffolds based on biodegradable polymers such as poly(lactic acid) and poly(lactic acid-co-glycolic acid) are weak and non-osteoconductive. For bone tissue engineering, polymer-based composite scaffolds containing bioceramics such as hydroxyapatite can be produced and used. The bioceramics can be either incorporated in the scaffolds as a dispersed secondary phase or … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,355 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGrowth of Bone Marrow Derived Osteoblast-Like Cells into Coral Implant Scaffold: Preliminary Study on Malaysian CoralK. A. AL-SalihiProblem statement: Biomaterial fabrication in Malaysia started as a consequence of the demand for cheaper implant materials. Various biomaterials have been developed utilizing local resources like Malaysian coral. Locally processed Malaysian coral need to be complemented with proper evaluation and testing including toxicology, biocompatibility, mechanical properties, physicochemical characterization and in vivo testing. The present study was carried out to assess … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 6,590 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDevelopment of Cell-Responsive Nanophase Hydroxyapatite for Tissue EngineeringR. Murugan, S. RamakrishnaScaffold plays a critical role in engineering bone tissues by providing necessary structural support for the cells to accommodate and guiding their growth in the three dimensional (3D) space. Therefore, designing scaffold that mimic composition and structural aspects of the bone is of great importance to promote cell adhesion, cell-matrix interactions, osteointegration, tissue formation and continued function. Nanophase hydroxyapatite (HA) … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 7,163 accessesView PDFCite
Research ArticleOpen accessIn the keywordsBioceramics for Tissue Engineering Applications-A ReviewSunho Oh, Namsik Oh, Mark Appleford, Joo L. OngThree dimensional (3-D) scaffolds have been explored in an attempt to persuade the body to heal or repair tissues that do not do so spontaneously. Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. However, the material and 3-D scaffolds ideal for optimal regeneration of missing or lost tissues has not been identified. While current … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 10,420 accessesView PDFCite
Research ArticleOpen accessIn the keywordsNanoceramic Matrices: Biomedical ApplicationsWilli Paul, Chandra P. SharmaNatural bone consisted of calcium phosphate with nanometer-sized needle-like crystals of approximately 5-20 nm width by 60 nm length. Synthetic calcium phosphates and Bioglass are biocompatible and bioactive as they bond to bone and enhance bone tissue formation. This property is attributed to their similarity with the mineral phase of natural bone except its constituent particle size. Calcium phosphate ceramics … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,361 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Optimization of a Porous Ti6Al4V Bone Construct Using Additive ManufacturingJeffrey Wilk, Glenn Sanders, Shelby Marks et al.Patient specific implants are becoming viable treatment options in some orthopaedic applications through advances in additive manufacturing and 3D printing techniques. One potential application is for treatment of segmental bone defects, particularly in patients suffering from bone cancer. Current treatment options are: Amputation, megaprosthesis, or allografts. These treatments are often highly invasive, may require a partial/full joint replacement and are … …American Journal of Engineering and Applied Sciences, Vol. 10, Issue 1 · 2 Jan 2017 · 7,811 accessesView PDFCite
Review ArticleOpen accessIn the abstractNews in Bone Modeling for Customized Hybrid Biological Prostheses DevelopmentRelly Victoria Virgil Petrescu, Raffaella Aversa, Valeria Perrotta et al.The complex biomechanics and morphologies of the femur proximal epiphysis are presented. The nature and fine morphology of the femur head and its structural behavior have been investigated. Isotropic and orthotropic trabecular structures have been associated with oriented compression and tensioned areas of the femur head FEM models. These isotropic/orthotropic trabecular morphologies and their allocations govern the stress and strain … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 14 Jun 2021 · 6,351 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdsorption Behavior of Bone Morphogenetic Protein-2 on a Graphite Substrate for Biomedical ApplicationsIzabele Marquetti, Salil DesaiThe interaction of proteins with biomaterials plays an important role for several biomedical applications including implants and tissue engineering. Although different experimental approaches have been explored, the investigation of the molecular models for protein-substrate interaction is warranted to control of cellular functions. In this study, Molecular Dynamics (MD) simulations were used to study the adsorption behavior of Bone Morphogenetic Protein-2 … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 19 Jun 2018 · 8,705 accessesView PDFCite
Research ArticleOpen accessIn the abstractHybrid Ceramo-Polymeric Nano-Diamond CompositesAntonio Apicella, Raffaella Aversa, Florian Ion Tiberiu PetrescuThis paper discusses a new class of bio-mechanical scaffolds active for tissue engineering based on a nano-diamond-filled hydrophilic polymer matrix. The new biomaterials used have special mechanical and biological properties for which they should be extensively studied for their use for various advanced biomedical applications. The new hybrid material has been prepared using 2 and 5% by volume of detonating … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 21 May 2018 · 8,616 accessesView PDFCite