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Author

Michel Leclerc

Independent Researcher: 556 Rue Isabelle Romee, France
11 articles in our journals

Articles where this person is an author, newest first. People are matched by their name as printed (no ORCID iD is recorded for them), not by name alone; search the name as text to find namesakes too.

Research ArticleOpen accessA NEW PRESUMED IGKAPPA GENE IMPLIED IN THE SEA STAR IMMUNE RESPONSEMichel Leclerc, Magne Osteras, Patricia OttenThe existence of another candidate IgKappa gene of 697 nucleotides, was recently, demonstrated, in the sea star Asterias rubens genome. This last gene was cloned and shown, with its sequence, in the present study. Its potential role in the sea star immune response was accentuated. …American Journal of Immunology, Vol. 10, Issue 1 · 19 Mar 2014 · 6,790 accessesView PDFCite
Research ArticleOpen accessANOTHER CANDIDATE IG KAPPA-LIKE GENE IN THE SEA STAR A. RUBENSMichel LeclercIn a recent paper we have shown that Ig Kappa genes (region MOPC 63, region K2), of 250 nucleotides each, were present in the sea star Asterias rubens. Two years later, a 697 nucleotide Ig Kappa chain V-V region K2 gene was accentuated. …American Journal of Immunology, Vol. 10, Issue 1 · 20 Dec 2013 · 6,761 accessesView PDFCite
Research ArticleOpen accessRevealed «Oncologic Markers» in the Sea Star Antibody Response to Horse-Radish PeroxydaseMichel Leclerc, Patricia OttenAt least two genes found in the genome of Asterias rubens after immunizations to the antigen Horse-Radish Peroxydase (HRP), could play the role of oncologic markers: The first one (Igkappa chain V-V region T 1 S 107 B precursor) reveals myeloma; The second (B cell CLL/Lymphoma 9-like) as the first one has a kinship to the IgKappa gene subfamily. …American Journal of Immunology, Vol. 9, Issue 4 · 16 Nov 2013 · 6,807 accessesView PDFCite
Research ArticleOpen accessA True New Gene: An Invertebrate Antibody Igkappa GeneMichel Leclerc, Nadine Vincent, Magne Osteras, Patricia OttenThe sea star Asterias rubens reacts specifically to the antigen: Horse-Radish Peroxydase (HRP) and produces an «antibody» anti-HRP.We had presented a candidate IgKappa gene corresponding to this last one in 2013. We show now the gene called: «sea star IgKappa gene» in its specificity. We have to know, at the present time that, at our knowledge, the sea star doesn’t … …American Journal of Immunology, Vol. 9, Issue 4 · 24 Sep 2013 · 7,009 accessesView PDFCite
Research ArticleOpen accessLike an Invertebrate Primitive AntibodyMichel LeclercSpecific immune responses occur in an invertebrate: The sea star Asterias rubens. Sea star T and B lymphocytes are present in the axial organ and coopere with phagocytes and Complement components to produce a primitive antibody correlated to Igkappa genes and to complement genes: It could be composed of 4 kappa chains and present strong and highly significant homologies to … …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 7,046 accessesView PDFCite
Research ArticleOpen accessA True &#34Candidate Ig Kappa Gene&#34 in the Sea-Star: Asterias rubens (Echinoderma)Michel Leclerc, Patricia Otten, Magne OsterasThe axial organ of the sea-star Asterias rubens is a primitive immune organ. The B-like cells, when stimulated by various antigens, produce antibody substances correlated with Ig Kappa gene. A candidate Ig kappa gene (IgK chain V-IV region S107B precursor) more convincing in term of genome was shown. …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 7,229 accessesView PDFCite
Research ArticleOpen accessEvidence of Interleukin Genes in the Sea-Star: Asterias rubens (Echinoderma)Michel Leclerc, Patricia OttenThe axial organ of the sea star Asterias rubens is a primitive immune organ the sea star T lymphocytes, when stimulated by various lectins, produce lymphokin-like substances with mitogenic properties as shown in earlier studies; they are correlated with Interleukin genes. …American Journal of Immunology, Vol. 9, Issue 2 · 22 Jun 2013 · 7,283 accessesView PDFCite
Research ArticleOpen accessComplement Genes in the Asterids Comparisons with the Echinids (Echinoderma)Michel LeclercThe axial organ of the sea star Asterias rubens (Asterid) is a primitive immune organ. The B-like cells, when stimulated by various antigens, produce antibody substances correlating with ig kappa genes. On the other hand, component complement genes were found. For each component, one or several contigs were analysed. It is said that Asterias forbesi, another sea-star, in earlier results, … …American Journal of Immunology, Vol. 9, Issue 1 · 26 Feb 2013 · 7,475 accessesView PDFCite
Research ArticleOpen accessHumoral Immune Responses to Various Antigens in the Asterids: A. gibbosa and A. rubensMichel LeclercImmunizations with various antigens of the sea stars Asterina gibbosa and Asterias rubens produce specific humoral immune reactions which initiate the antibody factor. This antibody factor is correlated with kappa genes and could be composed of 4 kappa chains. It is the first time that such phenomenom was described in an invertebrate. …American Journal of Immunology, Vol. 8, Issue 4 · 15 Feb 2013 · 7,309 accessesView PDFCite
Research ArticleOpen accessCell-Mediated Immune Responses in the Sea-Star Asterias rubens (Echinoderm)Michel LeclercCell-mediated immune responses occur in sea star system. In Asterias rubens it is said that B sea star lymphocytes and T sea star lymphocytes exist in the axial organ which can be considered as an ancestral lymphoid organ. In the same manner the origin of lymphocytes can be found in Invertebrates such as Echinodermal. …American Journal of Immunology, Vol. 8, Issue 4 · 29 Nov 2012 · 7,254 accessesView PDFCite