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Author

Manali Phadke

Temple University School of Pharmacy, United States
1 article in our journals

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Research ArticleOpen accessIs RNA Binding in the Rossmann Fold Essential for GAPDH Intranuclear Functions?Natalia Krynetskaia, Manali Phadke, Evgeny KrynetskiyIn addition to its prominent enzymatic activity, GAPDH is an enigmatic component of multiple unrelated biochemical entities. In this study, we explored a series of mutated GAPDH and fusion EGFP-GAPDH polypeptides and compared nuclear accumulation, intranuclear mobility and RNA binding properties of the wild type and variant GAPDH proteins. Our results revealed that RNA binding to T99I-mutated GAPDH with non-functional … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 2 · 14 Jun 2016 · 7,662 accessesView PDFCite