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38 articles for “antiretroviral”
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Research ArticleOpen accessEvery word in the titleAntiretroviral Toxicity and Oxidative StressAdikwu Elias, Brambaifa Nelson, Deo Oputiri, Oru-Bo Precious GeoffreyAntiretroviral drugs are used for the treatment of human immunodeficiency virus, they are used as combination regimens to achieve the highest possible benefit, tolerability, compliance and to diminish the risk of resistance development. Reports from preclinical and clinical studies have linked antiretrovirals with some toxicological effects which could be associated with redox imbalance (oxidative stress). This stimulated us to review … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 20 Nov 2013 · 8,255 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSurvival Analysis of Data of HIV Infected Persons Receiving Antiretroviral Therapy Using a Model-Based Binary Tree ApproachSimon Tiendrébéogo, Blaise Somé, Séni Kouanda, Simplice Dossou-GbétéDiscrete-time approach is used in survival data analysis when only the time interval in which the event of interest has occurred is known or when this event occurs in a discrete - time scale. The work presented in this paper is motivated by the analysis of HIV/AIDS follow-up data collected in Burkina Faso during the 5-YEAR Global Fund program implemented … …Journal of Mathematics and Statistics, Vol. 15, Issue 1 · 24 Dec 2019 · 6,495 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHigh Frequency of Stop Codons in the Human Immunodeficiency Virus-1 Protease Gene Frame in Human Immunodeficiency Virus+ Individuals with Below Detectable Levels of Plasma Viremia During Highly Active Antiretroviral TherapyMagdalena Czubala, Kabo Matlho, Maria Arriaga et al.We performed sequence analysis of HIV-1 proviral protease gene fragment (560 base pairs) amplified from ex-vivo peripheral blood mononuclear cells of 83 HIV+ individuals with Below Detectable Levels (BDL) (<20-40 RNA copies/ml plasma) and detectable levels of plasma HIV viremia while on HAART. Noteworthy was the systematic presence of stop codons identified only in the BDL group and not in … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 14 Nov 2012 · 8,073 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOptimal Control Techniques for the Role of Antiretroviral Therapy (ART) Abuse in HIV/AIDS Treatment DynamicsBassey Echeng Bassey, Adagba Odey HenryFrom the studies of HIV/AIDS transmission and treatment dynamicsusing mathematical modeling, literature reviews have shown that attention hadnot been given to the behavioral attitude of screen-aware infectives not readyto receive treatment, HIV-aware infectives that initiated treatment buttruncated only to resume treatment later (therapy abuse) and those onconsistent treatment protocols. Moreso, following the non-outright eradicationof the deadly HI-virus, recommendations have been … …Journal of Mathematics and Statistics, Vol. 18, Issue 1 · 24 Nov 2022 · 5,819 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleModelling the Efficacy of Antiretroviral Treatment in HIV Patients: Case of Dr George Mukhari Academic Hospital in Tshwane, Gauteng Province, South AfricaMadimetja Marcus Motshwane, Solly Matshonisa SeeletseThis paper used survival analysis to evaluate the efficacy of antiretroviral (ARV) treatment in HIV patients and also to determine if ARVs reduces the risk of HIV/AIDS. Secondary data were collected from files archived in Tshepang Clinic in Dr George Mukhari Academic Hospital in Tshwane, Gauteng Province of South Africa. Survival time was regressed on influential variables that affect survival. … …American Journal of Applied Sciences, Vol. 13, Issue 8 · 17 Aug 2016 · 7,768 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Effects of Protease Inhibitors on Metabolic Complications and Lipodystrophy in Human Immunodeficiency Virus-Infected PatientsMohd Khaza, K. Laxmi Prasad, M. EstariProblem statement: Highly Active Antiretroviral Therapy (HAART)-associated metabolic complications include lipoatrophy (loss of Subcutaneous Adipose Tissue (SAT) and insulin resistance. The risk of Diabetes Mellitus (DM) in Human Immunodeficiency Virus (HIV)-infected patients receiving Highly Active Antiretroviral Therapy (HAART) especially protease inhibitors has not been well defined. Approach: We conducted an analysis in the Hospital of Rajeev Gandhi Institute of Medical … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 6,934 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMortality among HIV-Infected Patients in Resource Limited Settings: A Case Controlled Analysis of Inpatients at a Community Care CenterNirmala Rajagopalan, Joyce B. Suchitra, Anita Shet et al.Problem statement: Despite massive national efforts to scale up Antiretroviral Therapy (ART) access in India since 2004, the AIDS death rate was 17.2 per 100,000 persons during 2003-2005. In the era of HAART in resource poor settings, it is imperative to understand and address the causes of AIDS related mortality. This collaborative study aimed at defining the predictors of mortality … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,661 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEfficacy of Pravastatin in Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) and Protease Inhibitor (PI)-based HAART in HIV-Infected PatientsSusan A. Eaton, Anita P. Rahman, Sean T. Nguyen et al.Pravastatin has generally been considered a safe and effective option for HIV-infected patients on highly active antiretroviral therapy (HAART). However, pravastatin concentrations are known to significantly decrease with concomitant efavirenz (EFV) use. Currently there are no studies determining if these reductions in pravastatin possibly translate into an attenuation of its lipid lowering efficacy when used in HIV-infected patients on non-nucleoside … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,959 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHIV Medication Adherence and Substance Use: The Smartest Women’s ProjectEliot Lopez, Deborah L. Jones, Mary Ishii et al.Antiretroviral (ARV) medication for substance users has been a controversial issue with respect to whether current substance users can successfully maintain their medication regimens. This study compared ARV adherence across current substance users, former substance users and those with no history or current use and the relative impact of a medication adherence intervention on all three groups. Of the 481 … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,193 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMetabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase InhibitorsMadhu N. Rao, Grace A. Lee, Carl GrunfeldThe use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection and AIDS has been associated with multiple abnormalities in glucose and lipid metabolism. Specifically, these abnormalities include insulin resistance, increased triglycerides and increased LDL cholesterol levels. The metabolic disturbances are due to a combination of factors, including the direct effect of medications, restoration to … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,936 accessesView PDFCite