2 articles for “antihypertensive activity”

Research ArticleOpen accessIn the keywordsSynthesis and Calcium Channel Blocking Activity of 1, 4-Dihydropyridine Derivatives Containing Ester Substitute and Phenyl Carbamoyl GroupBassem Sadek, Khairi Mustafa Salem Fahelelbom, Laurentiu Morusciag, Sigurd ElzProblem statement: Several studies on the synthesis of new nifedipine analogs have been carried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester with an amide (5-phenylcarbamoyl) moiety has been reported. Approach: Six new derivatives of m-nifedipine have been successfully synthesized by substituting an ester moiety with an amide … …American Journal of Applied Sciences, Vol. 8, Issue 4 · 18 Apr 2011 · 8,247 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCardiovascular Effect of Capparis spinosa Aqueous Extract. Part III: Antihypertensive Effect in Spontaneously Hypertensive RatsZeggwagh Naoufel Ali, Mohamed Eddouks, Jean Baptiste Michel et al.This study aims to evaluate the hypotensive activity of Capparis spinosa aqueous extract (CSAE) in spontaneously hypertensive (SH) rats. CSAE was lyophilised and administrated daily at a dose of 150 mg kg-1 for 20 days. CSAE administration produced a significant reduction in systolic blood pressure after eight days of oral administration (p 0.05) after 20 days of oral administration. We … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 9,327 accessesView PDF Cite