Research ArticleOpen accessIn the author namesOptimization of the Fermentation Medium of Streptomyces ahygroscopicus ΔnysB, a Tetramycin Producing Strain, by the Response Surface MethodXiao Wang, Yao Dong, Xin Chen et al.Streptomyces ahygroscopicus ΔnysB is a genetically engineered strain that produces tetramycin by blocking the competition nystatin pathway. Response Surface Methodology (RSM) was used to optimize its fermentation medium composition. Taking the yield of tetramycin as the response value, the effects of corn starch, glucose, fish peptone, (NH4)2SO4, KH2PO4, and CH3COONa on the yield of tetramycin were investigated by the Plackett-Burman … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 1 · 9 Apr 2024 · 5,327 accessesView PDFCite