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98 articles for “Wistar Rats”
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Research ArticleOpen accessPhrase in the titleAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,451 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleProtective Effects of Propolis on Gamma-Irradiated Nigella sativa Extract Induced Blood and Immune Changes in Wistar RatsOsama Moseilhy Saleh, Mohamed Mohamed Soliman, Ahmed Abdel-Khalik Mansour, Omniya Mahmoud Abdel-HamidThe present study conducted to test the effect of Nigella Sativa (NS, 5 mg kg-1 of body weight), or γ-irradiated Nigella Sativa (GRNS) on the changes of blood component profiles, liver, kidney functions and immune cytokines secretion in male Wistar rats. Moreover, the possible protection by propolis (200 mg kg-1 B. W.) on the changes induced by NS and GRNS … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 7,468 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleBiochemical Alterations Induced by Amylin in Wistar RatsMohamed Mohamed Soliman, Zein Shaban IbrahimAmylin is a peptide hormone synthesized in β cells of pancreas together with insulin in response to glucose and nutrients. Amylin controls food intake and body weight but the exact mechanism is still unknown. This study aimed to examine the effects of amylin injection on hormones, metabolites and cytokines expression in rats. Wistar rats were injected amylin Intraperitoneally (IP) (10 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 7 Jun 2013 · 6,771 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAluminium Chloride Exposure Had No Effects on the Epididymis of Wistar RatsSamuel Adeniyi Ojo, Joseph Olajide Hambolu, Sunday Samuel Adebisi, Adebayo Adekunle BuraimohAluminium is a ubiquitous element and one of the trace elements with moderate toxic effect on living organism. It is generally a recognized neurotoxin that is believed to be at the root cause of Alzheimer’s disease and third most abundant element in the earth’s crust after oxygen and silicon. Traditionally, aluminium has been considered as nontoxic to humans. However, in … …Current Research in Medicine, Vol. 3, Issue 2 · 25 Aug 2012 · 7,455 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAcute and Sub-acute Toxicity of Crataegus Aronia Syn. Azarolus (L.) Whole Plant Aqueous Extract in Wistar RatsAbdullah S. ShatoorProblem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 14,664 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleThe Influence of Garcinia kola Seed on Sexual Behavior and Testis Physiology in Wistar RatsJonah Sydney Aprioku, Victor Nwachukwu, Blessing Ukamaka Okeke et al.Garcina kola seed is believed by some to enhance male sexual performance but existing scientific data show divergent results. In this study, the sexual and reproductive influence of ethanol (70%) seed extract of G. kola was evaluated in Wistar rats. Adult male rats were gavaged with 0, 50, 100, 200 or 300 mg kg-1 day-1 of extract for 30 days … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 25 Apr 2018 · 13,815 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAMELIORATIVE EFFECT OF HIBISCUS SABDARIFFA LINN ON SUBCHRONIC CHLORPYRIFOS-INDUCED ALTERATIONS IN SEX AND THYROID HORMONES IN MALE WISTAR RATSShittu Muftau, Olatunji Omobolanle Aisha, Suleiman Folorunsho Ambali et al.Studies have shown that Chlorpyrifos (CPF), an Organophosphate (OP) insecticide alters both sex and thyroid hormones. Apart from inhibiting Acetylcholinesterase (AChE) activity, CPF has been shown to cause oxidative stress. The antioxidant potentials of many flavonoid-containing plants are increasingly being exploited in the therapy of many infectious and non-infectious diseases. Hibiscus Sabdariffa (HS) is one of the most widely used … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 20 Feb 2014 · 9,102 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleCinnamon Extract Regulates Gene Expression of Lipid and Carbohydrate Metabolism in Streptozotocin Induced Diabetic Wistar RatsMohamed Mohamed Soliman, Mohamed Mohamed Ahmed, Samir Ahmed El-ShazlyCinnamon is a herbal medication plant used widely for many diseases in the Middle East and ancient countries. Cinnamon Extract (CE) contains many active substances that modulate insulin sensitivity and acts as anti-diabetic medication. Diabetes mellitus is a disease characterized by disturbance in carbohydrate and lipid metabolism. The aim of this study was to examine the effect of Cinnamon Extract … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 8,048 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleVitamin C Alleviates Chronic Chlorpyrifos Induced Alterations in Serum Lipids and Oxidative Parameters in Male Wistar RatsS. F. Ambali, M. Shittu, J. O. Ayo et al.Problem statement: Although the increase incidence of cardiovascular diseases, obesity and diabetes mellitus has been attributed to changing life style, the role of environmental contaminants is currently being given considerable attention. Pesticides, including Organophosphate (OP) insecticides are one of the most pervasive environmental contaminants that are deliberately released into the environment. Chlorpyrifos (CPF), a widely used OP insecticide has been … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 4 · 21 Feb 2012 · 7,578 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleVitamin E Mitigates Chronic Chlorpyrifos-Induced Oxidative Changes in Pituitary Glands and Testes in Wistar RatsM. Shittu, J. O. Ayo, S. F. Ambali et al.Problem statement: The sperm counts of men have declined by about 50% in the last few decades. The contribution of environmental contaminants to this decline cannot be overemphasized. Pesticide is one of the most pervasive environmental chemical contaminants that have been of increased use due to the compelling need to feed the ever-growing world human and animal population and protect … …American Journal of Applied Sciences, Vol. 9, Issue 1 · 19 Nov 2011 · 7,315 accessesView PDFCite