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26 articles for “Transporter”
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Research ArticleOpen accessEvery word in the titleAMINO ACID TRANSPORTERS IN DRUG DISCOVERYMariafrancesca Scalise, Lorena Pochini, Michele Galluccio, Cesare IndiveriAdministered drugs interact with membrane transporters of epithelia, Blood Brain Barrier and other districts influencing their delivery and efficacy. Drugs can also be used as inhibitors of transporters involved in human pathology. Drug-transporter interactions are responsible of off-target effects contributing to toxicity. High Throughput Screening technologies increased the potential applications in therapy or in predicting side effects. These strategies will … …Current Research in Drug Discovery, Vol. 1, Issue 1 · 2 Oct 2014 · 7,099 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleExpression of Nucleoside Transporters in the Mouse Testis and OvaryKatsuhito Nagai, Hiroki KonishiNucleoside transporters play key roles in the physiology of nucleosides and nucleobases in mammals and also contribute to the pharmacological actions produced by their analogs. Several mammalian nucleoside transporters have been identified at the molecular level. The aim of this study was to examine the expression of the major nucleoside transporter isoforms in the mouse testis and ovary. Equilibrative Nucleoside … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 4 · 20 Dec 2013 · 6,978 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGeometry and Determining the Positions of a Plan Transporter ManipulatorRelly Victoria Virgil Petrescu, Raffaella Aversa, Antonio Apicella et al.The conveyor mechanism (working in a plan) to be presented in this study is a classic case of manipulating conveyor, simply with a single degree of mobility. It is a very common mechanism used in classical mechanics, being encountered at lifting platforms, at handicapped chairs, at cranes, forklifts, automatic machines and machines, or at older steam locomotives where it having … …Journal of Mechatronics and Robotics, Vol. 1, Issue 2 · 1 Jan 2018 · 6,551 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRole of Biopterin Transporter (BT1) Gene on Growth and Infectivity of LeishmaniaManju Jain, Vandana S. Dole, Peter J. Myler et al.Leishmania are known to be auxotrophic for pteridines that are known to play a critical role in the parasites survival. In the present work the role of biopterin transporter in the growth of the parasite and infectivity in to macrophages has been worked out. The role of biopterin transporter in the susceptibility of Leishmania to antimonial compounds has also been … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,038 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma MembraneHans Prenen, Cristiana Stefan, Bart Landuyt et al.Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,245 accessesView PDFCite
CorrigendumOpen accessEvery word in the titleCorrigendum: Geometry and Determining the Positions of a Plan Transporter ManipulatorRelly Victoria Virgil Petrescu, Raffaella Aversa, Antonio Apicella et al.Correction to: Journal of Mechatronics and Robotics http://doi.org/10.3844/10.3844/jmrsp.2017.118.126, published online January 1, 2018; updated April 29, 2019 The original version of this Article contained Mr. MirMilad Mirsayar as a co-author. Mr. Mirsayar has not contributed to the preparation and publication of this manuscript. These errors have now been corrected in the HTML and PDF versions of the Article. http://doi.org/10.3844/10.3844/jmrsp.2017.118.126. …Journal of Mechatronics and Robotics, Vol. 2, Issue 1 · 29 Apr 2019 · 5,982 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Glia Connection of the Glutamate/Glutamine ShuttleAngelina Rodriguez, Arturo OrtegaProblem statement: Glia cells outnumber neurons but their role in synaptic transmission is still matter of debate. The recycling of Glutamate, the main excitatory neurotransmitter, carried out by the glutamate/glutamine shuttle, requires the involvement of glia, suggesting their involvement in neurotransmission. Approach: This review focuses on novel functions of glia proteins involved in this cycle. Results: An activity-dependent interaction of … …Neuroscience International, Vol. 3, Issue 1 · 3 Sep 2012 · 7,770 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Sled Dog Model for Positive Health Effects of Weight Management and ExerciseLaura Falkenstein, Scott Jerome et al.Obesity is a significant risk factor for metabolic syndrome and type II diabetes. Physical activity and/or dietary modification can reduce the incidence of obesity. Marginal fitness levels limit the efficacy of exercise training, and most humans choose from a wide range of dietary strategies to lose weight. Despite these limitations, exercise in the absence of weight loss may offer protective … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 1 · 23 Feb 2023 · 6,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Metallothionein-Like Protein 2B Gene Induced by Different Concentrations of Copper in White Spruce (Picea glauca)Megan McKergow, Kabwe NkongoloThe alterations to the expressions of metal transporter genes can induce metal ion uptake to maintain cell homeostasis when metal concentrations are low. Metallothioneins (MTs) are a class of low molecular mass (4-8 kDa), cysteine (Cys)-rich proteins that can bind metals via the thiol groups of their Cys residues. Studies on MT gene expressions in higher plants, such as conifers, … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 25 Dec 2022 · 5,118 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Cinnamomum cassia Stem-Bark Extracts on the Synthesis and Secretion of Insulin in RIN-m5F CellsAnanias Hodi Kgopa, Sebolaishi Doris Makhubela, Motetelo Alfred Mogale, Leshweni Jerry ShaiCinnamomum cassia (C. cassia) crude stem-bark extracts possess some hypoglycemic properties through inhibiting the uptake of glucose by the intestines and/or enhancing insulin sensitivity. To further investigate the mechanism through which the hypoglycemic effect is exerted, this research explored the influence of the extracts of the crude stem-bark of C. cassia, with various polarities, on particular aspects of glucose consumption … …OnLine Journal of Biological Sciences, Vol. 22, Issue 2 · 5 Apr 2022 · 5,784 accessesView PDFCite