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33 articles for “Therapeutics”
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Research ArticleOpen accessEvery word in the titleEmploying New Mathematical Models and Equations to Evaluate Risk-Benefit Criteria of Clinical TherapeuticsDa Yong Lu, Ting Ren Lu, Jian DingCurrent preclinical and clinical evaluation of a drugs or therapy is at first to find out a maximum toxicity tolerance, which is overall fixed. The potential therapeutic dosage will be ranged just lower or within the periphery of these maximum tolerant data. A hidden acceptance among general researchers lies as the toxicity concentration of a drug is always the same … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 30 Jun 2007 · 6,825 accessesView PDFCite
EditorialOpen accessEvery word in the titleCURRENT SCENARIO OF THERAPEUTICS FOR EBOLA VIRUS DISEASEML Arvinda Swamy, Madhavan P.N. Nair, Shailendra K. SaxenaCurrently various countries in Africa, including Liberia, Sierra Leone, Guinea, Nigeria, are facing disaster due to Ebola Virus Disease (EVD), which is primarily caused by Ebola virus. 2014 outbreak of Ebola associated viral haemorrhagic fever has 55-60% fatality rate. The incubation period of Ebola is below 21 days; once the appearance of symptoms starts the person will be infective. As … …American Journal of Infectious Diseases, Vol. 10, Issue 3 · 3 Sep 2014 · 7,744 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMonoclonal Antibody-Based Therapeutics for Melioidosis and GlandersHyung-Yong Kim, Alexander Stojadinovic, Peter J. Weina et al.Problem statement: Burkholderia Pseudomallei (BP) and B. Mallei (BM) were two closely related pathogenic gram-negative bacteria. They were the causative agents of melioidosis and glanders, respectively and are recognized by CDC as category B select agents. Significant efforts had been devoted to developing the diagnostic and therapeutic measures against these two pathogens. Monoclonal antibody-based therapeutic was a promising targeted therapy … …American Journal of Immunology, Vol. 7, Issue 3 · 23 Dec 2011 · 8,975 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCurrent Advances in Zika Virus Transmission: Urgency for Effective Therapeutics and PreventionYash Raj, Swatantra Kumar, Amrita Haikerwal et al.Global emergence of Zika Virus (ZIKV) with prevalent outbreaks has been reported in numerous countries of South America, Central America and the Caribbean region. According to recent World Health Organization (WHO)-ZIKV situation report, 84 countries/territories/subnational areas represented with established mosquito-borne transmission of ZIKV. As of 10 August 2017, cumulative Zika cases and congenital syndrome associated with Zika virus reported by … …American Journal of Infectious Diseases, Vol. 13, Issue 2 · 2 Oct 2017 · 7,798 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleInitiatives to Improve the Quality of Life of HIV Positive Diagnosed Subjects: A Review of Diagnosis, Prognosis and Therapeutics under the Light of Science and EthicsMario Enrique Molina, Jeremías Abou Medelej, Jorgelina Zucchi, Carlos ManasseroThe first cases of AIDS occurred about 1981. There are not fully appropriate therapeutic interventions for treating this medical condition. People who are diagnosed HIV-positive or with AIDS suffer a poor quality of life and receive medication that produces severe adverse reactions. We have analyzed a significant number of papers published in several countries on these topics, and we have … …American Journal of Immunology, Vol. 13, Issue 3 · 3 Aug 2017 · 9,055 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleINTERVENTION OF PHARMACOGENETIC PROFILING IN THERAPEUTICS OF KASHMIRI POPULATION, A LESSON LEARNED FROM CYP3A5*3 VARIANTAshaqullah Bhat, Aadil Wani, Rajinder Kaur et al.Human Cytochrome P450 3A, a variant of Cytochrome P-450- dependent monooxygenases is a major drug metabolizing enzyme. CYP3A has evolved to catalyze the biotransformation of its substrate. A great deal of inter-individual variation in expression levels exists for CYP3A5 gene. The common polymorphism in CYP3A5 that induces a cryptic splice site has been shown to cause a significant reduction in … …OnLine Journal of Biological Sciences, Vol. 14, Issue 3 · 10 Jul 2014 · 7,215 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBIOENERGETICS, THE FOUNDATION OF THE FUTURE OF CANCER THERAPEUTICS A QUANTUM LEAP IN MAKINGKambiz AfrasiabiDeep understanding of the governing laws of bioenergetics of the living organism and dissection of their aberrancies, could enable us to design new treatment strategies for a vast array of disorders including malignancy and could potentially lead to major breakthroughs and cure of these devastating disorders. The modern treatment strategies currently aim at identification of a pathway considered to be … …OnLine Journal of Biological Sciences, Vol. 12, Issue 3 · 15 Aug 2012 · 7,528 accessesView PDFCite
Research NotesOpen accessIn the keywordsIndividualizing Periods of Commercial Exclusivity to Control Pricing for Drugs and BiologicsCallie M. Blase, Brandon K. Rouault, Maia B. Zoller et al.The pricing for immunologic agents and antibody-based therapeutics has increased precipitously in recent years. Among the key contributors to price hikes is the static practice of granting commercial exclusivity to innovator drugs and biologics. Herein, we present a mechanism for individualizing periods of commercial exclusivity to control pricing for drugs and biologics. …American Journal of Immunology, Vol. 15, Issue 1 · 13 Sep 2019 · 7,011 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCPI-1189 Protects Against Dextran Sulfate Sodium-induced Colitis in MiceBeverley Greenwood-Van Meerveld, Karl R. TylerNitrone-related therapeutics (NRTs) represent a new class of small molecules potentially effective in the treatment of inflammatory bowel disease (IBD) by protecting cells from damage caused by excess inflammation and/or oxidative stress. The goal of this study was to determine the efficacy and potency of CPI-1189, a novel therapeutic agent, in dextran sulfate sodium (DSS)-induced colitis in mice. Mice received … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 6,713 accessesView PDFCite
EditorialOpen accessIn the keywordsMechanisms and Management of Chronic PainVictor V. ChabanChronic pain symptoms account up to half of all health care visits, afflicts >10% of US adults, at a higher prevalence in women with current analgesic drugs rarely provide enough efficacy in the absence of serious side effects. Chronic pain is also the root cause of the national opioid health crisis, which adds to health care costs and deaths. Thus, … …International Journal of Research in Nursing, Vol. 12, Issue 1 · 14 Jan 2021 · 7,201 accessesView PDFCite