3 articles for “TLR9”

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Research ArticleOpen accessEvery word in the titleHepatoprotective Impact Of TLR9 Antagonist ODN 2088 Against Carbon Tetrachloride (CCl4)-Induced Hepatic InjuryBadr AlzahraniThe main objective of this study is to evaluate the hepatoprotective impact of TLR9 antagonist ODN 2088 against carbon tetrachloride (CCl4)-induced acute liver injury. In this study, 24 mice were grouped into four groups. CCl4 was introduced in all groups except for the control group intraperitoneally after pretreatment with ODN 2088 and silymarin for seven days. To assess the liver … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 4 Jan 2020 · 7,659 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleMarking of Genetic Resistance to Chlamydia, Brucellosis and Mastitis in Holstein Cows by Using Polymorphic Variants of LTF, MBL1 and TLR9 GenesIndira Beishova, Birzhan Nurgaliyev, Alena Belaya et al.The purpose of the research is to study the association of polymorphic variants of the Toll-Like Receptor 9 (TLR9), Mannose-Binding Lectin 1 (MBL1), and Lactoferrin (LTF) genes with the incidence of chlamydia, brucellosis and mastitis in Holstein cows. Samples of Holstein cows with established diagnoses of chlamydia, brucellosis, and mastitis were characterized by the nature of the correspondence of the … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 2 · 6 May 2023 · 6,157 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsCpG Oligodeoxynucleotides Debate the Damaging Action of Cisplatin on Immune Cell DNA: A PCR Array Application on Repair Genes ExpressionNaglaa Fathy Alhusseini, Amal Abo El-Fadl, Shabaan Hemada et al.Synthetic Oligodeoxynucleotides (ODN) expressing CpG motifs (CpG-ODN) mimic the immunostimulatory activity of bacterial DNA and are commonly used to activate Toll Like Receptor 9 (TLR9) for therapeutic applications. CpG-ODN can counteract the activity of DNA-damaging chemotherapy and radiation therapy on immune cell and enhance immunity in preclinical mouse models. We hypothesized that these actions of CpG-ODN on immune cells are … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 27 Jul 2016 · 7,625 accessesView PDF Cite