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32 articles for “Sprague Dawley Rat”
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Research ArticleOpen accessPhrase in the titleSafety Assessment of Indigenous Probiotic Strain Lactobacillus plantarum Mut-7 Using Sprague Dawley Rats as a ModelAtika Yahdiyani Ikhsani, Emma Riftyan, Rosa Amalia Safitri et al.Lactobacillus plantarum Mut-7 is a probiotic candidate isolated from gatot, traditional fermented cassava from Java, Indonesia. This study aimed to evaluate safety aspects of high dose consumption of L. plantarum Mut-7 (1011 CFU/ml/day) on Sprague Dawley rats for 21 days. Twenty four female rats were randomly divided into 4 groups; initial condition group (P.0), control group (P.1), skim milk group … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 30 Apr 2020 · 8,690 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleSafety Assessment of Indigenous Probiotic Strain Lactobacillus plantarum Dad-13 Isolated from Dadih Using Sprague Dawley Rats as a ModelEndang S Rahayu, Ilzamha H Rusdan, Armita Athennia et al.Lactobacillus plantarum Dad-13 is a probiotic candidate from dadih, a traditional fermented buffalo milk from West Sumatera, Indonesia. This study aimed to evaluate safety aspects of L. plantarum Dad-13 in high dose consumption on Sprague Dawley rats. Two treatment groups were fed with 1011 CFU/mL/day of L. plantarum Dad-13 for 14 and 28 days respectively. Two placebo groups were fed … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 12 Nov 2019 · 10,134 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAnti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley RatAlluri V. Krishnaraju, Chundi B.M. Rao, Dodda Sundararaju et al.Problem statement: Anti-inflammatory agents, particularly steroids and cyclooxygenase inhibitors are often associated with adverse side effects including, GI irritation, ulcers, hypertension and cardiac abnormalities. A safe and effective intervention is essential for the treatment of inflammatory disorders. Approach: Abstract Vitex leucoxylon L., a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. VL-89/185A, was … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,044 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEffect of Alloxan-Diabetes on Gastrin-Releasing Peptide (GRP) Immunoreactivity in the Gastrointestinal Tract, of Sprague Dawley Rats and How This May Affect Some of the Diabetic ComplicationsEdward O. Uche-Nwachi, Camille V. MitchellGastrin-releasing peptide (GRP) is the mammalian analogue of bombesin. Both neuroendocrine peptides have similar distribution, functions and immunoreactivity. The immunoreactivity for GRP has been demonstrated in the esophagus, stomach and small intestine. This peptide is reported to have various biological and pharmacological properties, which include the release of gastrointestinal hormones, control of satiety, gastrointestinal motility and stimulation of cellular proliferation … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 31 Dec 2007 · 7,250 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAcute and Sub-Acute Toxicological Assessment of Aqueous Leaf Extract of Bryophyllum Pinnatum (Lam.) in Sprague-Dawley RatsRaymond Iduojemu Ozolua, Sylvester Eshiotseme Idogun, Glory Eshiagiamhe TafamelProblem statement: The aqueous leaf extract of Bryophyllum pinnatum has been reported to possess antihypertensive, antiinflammatory, antimicrobial, antidiabetic and antiulcer properties among others. Being readily available and easy to cultivate, the use of the plant in herbal medicine has been on the increase. Although there are few toxicological reports on the extract, these have not been sufficiently extensive. We therefore … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 9,379 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntidiabetic and Antioxidant Potential of Vernonia amygdalina Leaf Extract in Alloxan-Induced Sprague-Dawley RatsFatmawaty Yazid, Nina Bonita Hasanah, Rosmalena et al.The treatment of diabetes mellitus using drug medications have side effects such as weight gain, hypoglycemia, the risk of cardiovascular or all-cause mortality. These limitations have become one reason to use complementary therapy from plant extract, such as Vernonia amygdalina as an antidiabetes. This research aimed to investigate the effect of V. amygdalina leaf extracts as antidiabetic and antioxidant agents … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 23 Nov 2020 · 8,649 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMicroscopic Study of the Lungs of Sprague-Dawley Rats from Various Ages of Postnatal and Aging PeriodsRia Margiana, Isabella Kurnia Liem, Jeanne Adiwinata PawitanPhysiological changes in postnatal and aging lung are associated with a variety of microscopic changes in the lung, especially the alveolar lung tissue, both in the interstitial and epithelial component. Interstitial tissue of the lung will increase in thickness that is supposed to be due to changes in fiber composition, particularly collagen. However, the exact changes are still under debate … …OnLine Journal of Biological Sciences, Vol. 15, Issue 2 · 13 Jun 2015 · 7,312 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleABSENCE OF VISIBLE TOXIC EFFECTS ACCOMPANYING THE SHORT-TERM ADMINISTRATION OF AN AQUEOUS EXTRACT OF ALLIUM SATIVA LINN. IN MALE SPRAGUE-DAWLEY RATSJ. Asiedu-Gyekye Isaac, Awortwe Charles, A. Antwi DanielAllium sativum is cultivated in the northern part of Ghana and has gained widespread use as chemoprotective, in curing hypertension, impotence and erectile dysfunction. The multipurpose use together with its aphrodisiac activity has resulted in the widespread use of this plant medicine both in meals and as herbal medications. Safety assessment of this plant however is rare. The present study … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 30 Jan 2014 · 7,577 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley RatA. K. Sairah, A. Rasedee, O. Sheikh et al.Problem statement: Erythropoietin receptor (EPOR) has been detected in breast cancer cells and speculated to be involved in cancer growth, viability and angiogenesis. This has risen suspicious that EPO administration may enhance the severity of cancer. Approach: This study was undertaken to determine the effects of rHuEPO, Tamoxifen and their combination on the growth and angiogenesis of mammary tumor. Female … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 7,804 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAlbusite: A Novel Synthetic Gel for Promotion of Skin Wound Healing in RatsShahram Jahanabadi, Mohammad Yasin Karami, Shahram Paydar et al.The current study was performed to evaluate the effect of Albusite gel on the healing process of excisional wounds in diabetic and control rats. Fifty-two Sprague Dawley male rats were used to evaluate the effects of Albusite Gel (synthetic gel) on the healing of full-thickness skin wounds. The control group (n = 2 6) and study group (n = 26) … …OnLine Journal of Biological Sciences, Vol. 15, Issue 3 · 26 Jun 2015 · 7,040 accessesView PDFCite