Research ArticleOpen accessIn the keywordsSclerostin: A Novel Key to Bone and Dental TreatmentGalli Carlo, Lumetti Simone, Manfredi Edoardo et al.Problem statement: Tooth loss can induce dramatical remodeling of alveolar bone because of mechanical loading impairment and strategies to help maintain adequate bone levels for subsequent therapies are sorely needed. Recent discoveries have shown that osteocytes, matrix-embedded cells in bone, respond to mechanical stimulation by modulating the expression of the Sost gene, which encodes for the protein sclerostin. This protein … …Current Research in Dentistry, Vol. 3, Issue 1 · 1 Jan 2013 · 8,157 accessesView PDFCite