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5 articles for “Somatic Stem Cells”
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Research ArticleOpen accessIn the keywordsTissue Engineering of Articular Cartilage: A Mini-ReviewRadoslav Zamborsky, Jana Rusnakova, Andreas NicodemouDamage of articular cartilage due to congenital anomaly, injury or pathological process may lead in decreasing of life quality of affected patients. In many cases, conventional therapeutical approaches may not bring expected results. Tissue engineering by the combination of material technology and cell-based therapy may represent hope for these patients. The main goal of this review article is to summarize … …OnLine Journal of Biological Sciences, Vol. 14, Issue 4 · 5 Jan 2015 · 6,925 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIN VITRO TESTING OF MODIFIED COLLAGEN/ HYALURONAN/BETA-GLUCAN SCAFFOLDJan Vojtassak, Dusan Bakos, Martin Bohac et al.Cells and scaffolds belong to main components of tissue engineering. In this study we have performed in vitro cytotoxicity and biocompatibility testing of modified collagen/hyaluronan/beta-glucan scaffold. We used direct contact assay as well as MTT test. Human adipose tissue-derived stem cells were used as biological model. According to obtained results, we can summarize, that modified collagen/hyaluronan/beta-glucan scaffold is non-toxic and … …OnLine Journal of Biological Sciences, Vol. 13, Issue 2 · 12 Jun 2013 · 7,214 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Serial Passaging on the Morphology and Biological Characteristics of Human Adipose Tissue-derived Stem CellsLenka Oravcova, Martin Bohac, Lubica Krajciova et al.Somatic stem cells posses an exclusive property of self regeneration and plasticity which makes them promising candidates for use in tissue engineering and regenerative medicine. In the case of stem cell therapy it is crucial to obtain them in sufficient amount. That's why they have to be cultured under in vitro conditions. Long term culture provides adequate number of cells, … …OnLine Journal of Biological Sciences, Vol. 16, Issue 4 · 17 Dec 2016 · 7,242 accessesView PDFCite
Research ArticleOpen accessIn the abstractINDUCED PLURIPOTENT STEM CELLS AND THEIR IMPLICATION FOR BIOMEDICAL SCIENCESMaria Csobonyeiova, Stefan Polak, Lubos DanisovicThe groundbreaking discovery, that somatic mammalian cells can be epigenetically reprogrammed to a pluripotent state through the exogenous expression of the transcription factors Oct4, Sox2, Klf4 and c-myc, has yielded a new cell type for potential application in regenerative medicine, the induced Pluripotent Stem Cells (iPSCs). Since the first demonstration of creating iPSCs in 2006 great efforts have been made … …OnLine Journal of Biological Sciences, Vol. 13, Issue 4 · 3 Oct 2013 · 7,024 accessesView PDFCite
Research ArticleOpen accessIn the abstractEpigenetic Mechanisms in Hepatitis C Virus-Associated Hepatocellular Carcinoma: A Potential New Link Between Stem Cells, Virology and CancerQinghua Feng, Sajida Hassan, Trina Das et al.Recent studies suggest that epigenetic mechanisms are not only essential for the dynamic transcriptional regulation in embryonic and somatic stem cells, but are also actively involved in tumorigenesis: genes important for pluripotency are epigenetically regulated and aberrant epigenetic changes have been detected in virtually all human malignancies studied, including Hepatocellular Carcinoma (HCC). Infection with Hepatitis C Virus (HCV) is a … …Current Research in Medicine, Vol. 4, Issue 1 · 12 Mar 2013 · 8,038 accessesView PDFCite