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10 articles for “Placebo patients”
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Research ArticleOpen accessEvery word in the titleQuality of Life in Hematologic Cancer Patients: A Randomized Clinical Trial of Low Dose Naltrexone Versus PlaceboMohammad Ali Seifrabiei, Mohammad Abbasi, Ali Montazeri et al.This study aimed to investigate its effect on hematologic cancer patients. This was a randomized controlled trial assessing quality of life in patients with hematologic malignancies from a single institute in Hamedan. Patients were allocated into two study arms and in addition to their routine treatment received either daily naltrexone 3 mg capsules (treatment group) or 3 mg starch (placebo … …American Journal of Applied Sciences, Vol. 5, Issue 7 · 31 Jul 2008 · 7,399 accessesView PDFCite
Research ArticleOpen accessIn the keywordsWhat Else do Epileptic Data RevealRamalingam ShanmugamProblem statement: Aggregating and analyzing data of all patients using statistical methodologies as often done in macro sense would be not useful when physician’s professional interest was only to provide the best medical care to the patient. For this purpose, individual data of the involved patient should be analyzed and modeled in a micro sense for the physician to notice … …Current Research in Medicine, Vol. 2, Issue 1 · 29 Mar 2011 · 7,302 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
Research ArticleOpen accessIn the abstractAlzheimer’s Disease Prognosis is Captured by a Down-Upsized Incidence Poisson DistributionRamalingam ShanmugamAlzeimer disease is a daunting nightmare to both the medical and families of the patients. Tireless efforts are made by the medical researchers to treat Alzheimer’s patients. The Alzhiemer patients’ data provides clues about its prognosis and they can be identifies when the data are analyzed and understood correctly. The data analysis is a first step in the path to … …Current Research in Medicine, Vol. 4, Issue 2 · 4 Sep 2013 · 6,926 accessesView PDFCite
Research ArticleOpen accessIn the abstractIs Cancer Recurrence Postponed By a Treatment? A New Model AnswersRamalingam ShanmugamDuring a treatment period of a cancer patient, the medical team ponders over a question: Is patient’s cancer recurrence significantly postponed by the medication, even if the illness is not completely cured? This question could be answered with data evidence if the data are analyzed with an appropriate model and a suitable methodology. A scanning of the literature reveals that … …Current Research in Medicine, Vol. 4, Issue 1 · 26 Mar 2013 · 6,887 accessesView PDFCite
Research ArticleOpen accessIn the abstractCase Report of Severe Injection Site Reaction Associated with Intramuscular NaltrexoneJill A. Covyeou, Katharine E. Atto, Chadwick W. Howard, Jessica R. SchultzProblem statement: To report a case of severe injection site reaction at the site of an IM naltrexone injection in a 30 year old female. Approach: A 30 year old female, being treated with naltrexone extended-release injectable suspension for alcohol dependence, presented with a mass on her left upper gluteal area at the site of injection. The injectable naltrexone was … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 7 Jun 2011 · 7,661 accessesView PDFCite
Research ArticleOpen accessIn the abstractSafety and Efficacy of an Ayurvedic Formulation Cystone in Management of Ureteric Calculi: A Prospective Randomized Placebo Controlled StudyN.K. Mohanty, R.L. Nayak, Pralhad S. PatkiProblem statement: Medical management of urolithiasis is still a challenge for modern medical practice. In the present study, Cystone tablet, an Ayurvedic formulation claimed to be useful in urolithiasis was evaluated for its safety and efficacy in reduction or expulsion of ureteric calculi and to assess the role of Cystone in relieving the clinical symptoms. Approach: This was a prospective … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 12,360 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Local Injection of 0.5% Bupivacaine + 1/200000 Epinephrine for Post Tonsillectomy Pain ReductionKeramat Mozafarinia, Maryam AmizadehTo determine the effectiveness of postoperative local infiltration of Bupivacaine in decreasing post tonsillectomy pain. A double blind randomized clinical trail was conducted. Treatment group was administered 3-10 ml 0.5% Bupivacaine + 1/200000 Epinephrine solution and control group was received 3-10 ml normal saline, locally. Outcome was post surgical pain, which measured by visual analogue scale (VAS), after 6, 12, … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,659 accessesView PDFCite
Research ArticleOpen accessIn the abstractTopical Cyclosporine A in Corneal Graft RejectionMahmood Nejabat, Jafar Khoshghadam, Masoomeh Eghtedari, Hamid HosseiniCorneal graft rejection is now the most common cause of graft failure after penetrating keratoplasty. This study was designed to determine whether, addition of 2% topical cyclosporine (CSA) to local and systemic steroids in treatment of endothelial corneal allograft rejection, would improve the outcome. A prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,317 accessesView PDFCite