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13 articles for “Neuropathy”
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Research ArticleOpen accessEvery word in the titleOptic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial ToxicityConnor Dyer, Katlyn Droke, Ugne Zekonyte, Mariana RoscaDeleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 19 Jan 2024 · 8,562 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleREMEDIAL EFFECTS OF VITAMIN E AND L-ARGININE ON PERIPHERAL NEUROPATHY IN STREPTOZOTOCIN-INDUCED DIABETIC RATSIsmaeel Bin-Jaliah, Samah El-Attar, Eman F. Khaleel et al.It was shown that hyperglycemia in diabetic patients is the main factor of diabetic peripheral neuropathies. Various pathways related to oxidative stress, vascular defect and defective endothelium dependent relaxation have been implicated in the development of diabetic peripheral neuropathy. A substantial number of studies have shown that antioxidant treatment are promising therapeutics that can prevent or correct reduced motor nerve … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 23 Dec 2013 · 8,041 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSensory Neuropathy Associated with Glucose Intolerance: A 35 Patients StudyGiseli Quintanilha, Osvaldo J.M. Nascimento, Marco Orsini, Camila PupeProblem statement: Peripheral neuropathy due to diabetes has been studied for several decades. Until recently, we associate the involvement of peripheral nerves with an inappropriate glycemic control in the most advanced stages of the disease. Currently, it is considered that the onset of the neural injury can occur in the initial phase of this metabolic abnormality, during the period of … …Neuroscience International, Vol. 2, Issue 1 · 26 Jul 2011 · 7,480 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleProtective Effect of Enicostemma littorale Blume on Rat Model of Diabetic NeuropathyNiraj Mukundray Bhatt, Suparna Barua, Sarita GuptaProblem statement: Poor glycemic control and oxidative stress is implicated as a common pathway in the development of diabetic neuropathy. Approach: In the present study, we investigated the protective effects of Enicostemma littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: Tail flick latency in hot immersion … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,838 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Beneficial Effect of Asiaticoside on Experimental Neuropathy in Diabetic RatsChonlathip Thipkaew, Jintanaporn Wattanathorn, Supaporn MuchimapuraThough diabetic neuropathy produces high impact on quality of life, annual cost and morbidities, the therapeutic efficacy is still not in a satisfaction level. Based on the crucial role of oxidative stress on the pathophysiology of diabetic neuropathy and the improvement of this condition induced by antioxidant, we hypothesized that asiaticoside, a substance possessing antioxidant activity, could provide beneficial effect. … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 31 Aug 2012 · 7,051 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffects of Melatonin in Prevention of Neuropathy in STZ-Induced Diabetic RatsNasser Zangiabadi, Vahid Sheibani, Majid Asadi-Shekaari et al.Problem statement: Diabetes mellitus occurs mainly with chronic polyneuropathy, and oxidative stress plays an important role in emergence of most neurologic and behavioral changes in diabetic patients. Many studies have focused on the beneficial effects of various antioxidants such as melatonin on diabetic neuropathy. The aim of this study is to evaluate the effect of melatonin in prevention of neuropathy … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Sep 2011 · 9,358 accessesView PDFCite
Case ReportOpen accessIn the keywordsHepatitis B-Related Mononeuritis MultiplexBudha Charan Singh, Vinay N Gowda, Prasan Kumar PandaHepatitisB Virus (HBV) infection can present with varied multisystem manifestationsinvolving the skin, kidneys, blood, and nervous system. We report a 57-year-oldman with HBV-related mononeuritis multiplex who had symptoms of multiplesensory-motor axonal polyneuropathies. He was evaluated for his neuropathy withnerve conduction studies and a sural nerve biopsy that revealed necrotizingsmall-vessel vasculitis. He also hadan acute liver injury. He was started on … …American Journal of Infectious Diseases, Vol. 18, Issue 4 · 16 Nov 2022 · 5,719 accessesView PDFCite
Research ArticleOpen accessIn the keywordsElectro-diagnostic and Clinical Changes of Peripheral Neuropathies in Bam Earthquake VictimsNaser Zangiabadi, Mohammad Naeem AhrariTo examine and diagnose patients who injured in Bam earthquake at 5:26:52 Am (local time) on Friday, December 26, 2003 with traumatic peripheral neuropathies then treat and follow up. A longitudinal study was deigned. 159 patients with traumatic neuropathies were selected at the first stage of study. After six months follow up only 39 patients satisfied to enter the study. … …American Journal of Environmental Sciences, Vol. 1, Issue 3 · 30 Sep 2005 · 6,712 accessesView PDFCite
Case ReportOpen accessIn the keywordsAlcohol-Induced Rhabdomyolysis Complicated by Hyponatremia and Acute Kidney Injury Following Minor Trauma: A Case ReportVinay Tulsian, Drupad Das, M Sukumar, Prasan Kumar PandaRhabdomyolysis from alcohol is established, but combined binge intake, minor trauma, and vomiting-induced hyponatremia is a complex clinical scenario. Case study: This case report describes a young male with a three-year history of alcohol consumption who presented with rhabdomyolysis following binge drinking and a mild traumatic fall. He experienced 10 to 15 episodes of vomiting post-alcohol intake, subsequently developing anasarca. … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 23 May 2026 · 1,700 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Effect of Omega-3 Fatty Acids on Nerve Conduction Velocity (NCV) and F-wave Latency in Patients with Diabetic polyneuropathyNaser Zangiabadi, Mohamad N. Ahrari, Nouzar NakhaeeDiabetes mellitus with the prevalence rate of 8.9-12.3% in human population, ultimately leads to the peripheral nervous system involvement in many patients. It causes various types of polyneuropathies, which may manifest abnormalities such as impaired nerve conduction velocity (NCV) and prolonged F-wave latency. The aim of this study was to investigate the effect of omega-3 fatty acids on NCV and … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 9,272 accessesView PDFCite