Research ArticleOpen accessPhrase in the titleMaternal Infection and Neurodevelopmental Disorders in the OffspringHeping ZhouProblem statement: Neurodevelopmental disorders such as schizophrenia and autism have been attributed to both genetic and environmental factors. Whether and how maternal infection as an environmental factor contributes to the development of neurological abnormalities in the offspring remains to be clearly defined. Approach: The literature was reviewed to examine the relationship between maternal infection and neurological disorders such as schizophrenia … …American Journal of Immunology, Vol. 8, Issue 1 · 12 Mar 2012 · 8,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractAutism Detection from 2D Transformed EEG Signal using Convolutional Neural NetworkZahrul Jannat Peya, M. A. H. Akhand, Jannatul Ferdous Srabonee, Nazmul SiddiqueAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder relating to speech complications, nonverbal and social communication, and repetitive behaviors. There is no remedy for ASD but early diagnosis, mediation, and supportive care can aid the development of language, conduct, and communication skills. As the cause of ASD is a neurodevelopmental disorder, its diagnosis based on brain function analyzing different brain … …Journal of Computer Science, Vol. 18, Issue 8 · 31 Jul 2022 · 7,921 accessesView PDFCite
Review ArticleOpen accessIn the abstractEEG-based Processing and Classification Methodologies for Autism Spectrum Disorder: A ReviewGunavaran Brihadiswaran, Dilantha Haputhanthri, Sahan Gunathilaka et al.Autism Spectrum Disorder is a lifelong neurodevelopmental condition which affects social interaction, communication and behaviour of an individual. The symptoms are diverse with different levels of severity. Recent studies have revealed that early intervention is highly effective for improving the condition. However, current ASD diagnostic criteria are subjective which makes early diagnosis challenging, due to the unavailability of well-defined medical … …Journal of Computer Science, Vol. 15, Issue 8 · 23 Aug 2019 · 10,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractUNUSUAL SPECTRUM OF GENETIC PATHOLOGIES AND NOVEL MUTATIONS IN PWS AND AS PATIENTS DETECTED BY A WIDE CLUSTER OF METHODSLivia Kotysova, Robert Petrovic, Jan ChandogaPrader-Willi and Angelman syndromes are clinically distinct neurodevelopmental genetic disorders that map to 15q11.2-q13 locus. The common phenotypes are attributable to loss of expression of parentally specific imprinted genes inside this region, where the gene function is dependent on parental origin. Initial diagnosis was proved for the years by methylation pattern analyses of the SNRPN exon 1/promoter region within the … …OnLine Journal of Biological Sciences, Vol. 14, Issue 3 · 12 Nov 2014 · 7,006 accessesView PDFCite
Research ArticleOpen accessIn the abstractChildhood Mental Disorders and Risk of SchizophreniaWenbin Liang, Tanya ChikritzhsProblem statement: Schizophrenia is one of the most serious forms of mental diseases, but the etiology of schizophrenia is still not well understood. Investigations are required to gain better understanding of the pre-onset course of schizophrenia. Approach: This study was a population-based birth-cohort study of males born between 1980 and 1984 in Western Australia (WA). Males were identified using birth … …Current Research in Medicine, Vol. 3, Issue 1 · 28 Feb 2012 · 7,698 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidence of Oxidative Stress in Autism Derived from Animal ModelsXue Ming, Michelle A. Cheh, Carrie L. Yochum et al.Autism is a pervasive neurodevelopmental disorder that leads to deficits in social interaction, communication and restricted, repetitive motor movements. Autism is a highly heritable disorder, however, there is mounting evidence to suggest that toxicant-induced oxidative stress may play a role. The focus of this article will be to review our animal model of autism and discuss our evidence that oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,115 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Neurodevelopmental Genes in Infectious Etiology of AutismS. Hossein FatemiAutism is a neurodevelopmental disorder with both genetic and environmental etiologies. Prenatal infections may play a role in evolution of autism. Experimental evidence shows human influenza viral infection in pregnancy leads to significant deleterious effects in brain structure and function in the developing mouse progeny. Several brain genes of interest in this animal model are also involved in the pathology … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 6,563 accessesView PDFCite
Research ArticleOpen accessIn the abstractAltered Sulfur Amino Acid Metabolism In Immune Cells of Children Diagnosed With AutismJung H. Suh, William J. Walsh, Woody R. McGinnis et al.Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental disorder whose etiology is poorly understood. Recent studies have shown that autistic children may be experiencing increased inflammation and oxidative stress. Altered immune regulation may be one contributing factor to inflammation and oxidative stress in autistic children. Sulfur amino acid (SAA) metabolism plays a critical role in regulating blood leukocyte functions … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 10,789 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Chromosomal Abnormalities, inv(5)(p13q13) and t(7;18)(q32;q21), Associated with AutismZheng Chen, Xiao-bing Zou, Ya-nan Zhang et al.Autism is a neurodevelopmental disorder defined by impairments in social interaction, communication, as well as restricted and stereotyped behaviors. While the etiology of autism remains largely unknown, the existence of genetic components has been clearly demonstrated in autistic pathogenesis. The incidence of autism is 50-100 fold greater in the population with autistic family history than the general population. Chromosomal abnormalities … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 6,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractBeta-2-Microglobulin in Autism Spectrum DisordersPaula Goines, Joseph Schauer, Luke Heuer et al.Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental diseases of unknown etiology. There are no biological markers for ASD and current diagnosis is based on behavioral criteria. Recent data has shown that MHC I, a compound involved in adaptive immune function, is also involved in neurodevelopment, synaptic plasticity and behavior. It has been suggested that altered MHC I expression could play … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 7,560 accessesView PDFCite