3 articles for “MDR1”

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Research ArticleOpen accessEvery word in the titleFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleGenetic Mutation Assessment of NPM1 Gene and Gene Expression of MDR1 in Iraqi Patients with Acute Myeloid LeukemiaAhmed Abduljabbar Suleiman, Ali Zaid Al-Saffar, Tamadher Abbas Rafaa, Hasan Abdulwahab JwadSince its discovery, mutations in NPM1 have been frequently associated with a large number of Acute Myeloid Leukemia (AML) patients. The vast majority of genetic changes were previously detected in exon 12, however little information report mutations in Nuclear Export Signal region (NES) of NPM1. Sequencing analysis included exon 2 and 3 for 75 Iraqi AML patients showed three SNPs, … …OnLine Journal of Biological Sciences, Vol. 18, Issue 1 · 11 Jan 2018 · 7,782 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIdentification and Antiproliferative Activity Evaluation of a Series of Triterpenoids Isolated from Flueggea virosa (Roxb. ex Willd.)Sod Monkodkaew, Chatchanok Loetchutinat, Narong Nuntasaen, Wilart PompimonProblem statement: Medicinal plants derived anticancer were now being subjects of many research groups especially, the secondary metabolite triterpenoids trees which had enormous potential to inspire and influence modern antiproliferative research. The study aimed to investigate the chemical constitution and their potential use as antiproliferative activity of purified compounds derived from F. virosa. Approach: The F. virosa was selected and … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 30 Oct 2009 · 7,626 accessesView PDF Cite