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27 articles for “MDR”
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Research ArticleOpen accessEvery word in the titleCirculation of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium Tuberculosis Strains in MexicoCarlos A. Vazquez-Chacon, Armando Martinez-Guarneros, Susana Balandrano Campos et al.Emergence of Extensively Drug-Resistant (XDR) Tuberculosis (TB) is an important public health problem worldwide. In Mexico, the extent of circulation of XDR-TB strains is unknown. Here, the drug-resistance patterns of TB isolates collected in Mexico between 2006 and 2008 were analyzed. Among 137 TB isolates, (58%) were classified as MDR exclusively, (33%) were Pre-XDR and (9%) were assigned as XDR. … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 7,422 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDFCite
Review ArticleOpen accessEvery word in the titleMultidrug Resistant Microorganisms (MDR) and Biofilm Producers: A Challenge for Hospital Infectious ControlDaniel Lucio, Elizabeth Proaño, Alberto Bustillos et al.Antimicrobial Resistance (AMR) now represents a major threat to contemporary health care, especially in hospitals, where repeated antimicrobial exposure selects for and facilitates the dissemination of Multidrug-Resistant (MDR) microorganisms. Biofilm growth adds another layer of persistence by increasing microbial tolerance, supporting long-term colonization of medical devices, and worsening clinical and economic outcomes. This narrative review synthesizes evidence on MDR biofilm-forming … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 3 · 12 Sep 2026 · 774 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleComputing MDR-Game with Applications to Real DataJimbo Henri Claver, Takeru Suzuki, Jesus Pascal et al.Originally developed for probability and statistic purposes, Multiple Dice Rolling (MDR) game turns out to be useful for many other applications such as complex biological systems and medical research. It has been mainly used to estimate system states that cannot be observed directly. MDR game is affected by noise and fluctuations. It is widely agreed that noise in dynamic systems … …Journal of Computer Science, Vol. 14, Issue 7 · 17 Jul 2018 · 7,789 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGenetic Mutation Assessment of NPM1 Gene and Gene Expression of MDR1 in Iraqi Patients with Acute Myeloid LeukemiaAhmed Abduljabbar Suleiman, Ali Zaid Al-Saffar, Tamadher Abbas Rafaa, Hasan Abdulwahab JwadSince its discovery, mutations in NPM1 have been frequently associated with a large number of Acute Myeloid Leukemia (AML) patients. The vast majority of genetic changes were previously detected in exon 12, however little information report mutations in Nuclear Export Signal region (NES) of NPM1. Sequencing analysis included exon 2 and 3 for 75 Iraqi AML patients showed three SNPs, … …OnLine Journal of Biological Sciences, Vol. 18, Issue 1 · 11 Jan 2018 · 7,782 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMultidrug Resistant Uropathogens among Egyptian Pregnant WomenWafaa Salah Metwally, Walid Mohamed ElnagarUrinary Tract Infections (UTIs) in pregnancy is a common medical problem associated with significant increase in the risk of fetal morbidity and mortality. The effective appropriate antimicrobial agent is a major concern as many effective antimicrobial groups cannot be used due to their potential toxicity to the fetus as well as the increasing rates of Multidrug-Resistant (MDR) strain isolation. This … …American Journal of Infectious Diseases, Vol. 15, Issue 4 · 21 Dec 2019 · 7,487 accessesView PDFCite
Review ArticleOpen accessIn the keywordsScope and Perspectives of New TB Drugs and VaccinesJaishree Meena, Laxman S. MeenaTuberculosis remains a major threatening infectious disease claiming millions of lives every year; hence increasing the global burden of TB disease. Co-infection with human immuno-deficiency virus and emergence of multi-drug resistant tuberculosis, extremely drug resistant tuberculosis and totally drug resistant tuberculosis enhances deadly effect of tuberculosis. To eliminate TB disease from human population several partnerships are working together like Stop … …American Journal of Infectious Diseases, Vol. 11, Issue 3 · 10 Sep 2015 · 7,943 accessesView PDFCite
Research ArticleOpen accessIn the keywordsQuercetin, Quercetrin Except Rutin Potentially Increased Pirarubicin Cytotoxicity by Non-Competitively Inhibiting the P-Glycoprotein-and MRP1 Function in Living K562/adr and GLC4/adr CellsWinit Choiprasert, Nathupakorn Dechsupa, Suchart Kothan et al.Problem statement: Quercetin and its glycoside derivatives are increasingly receiving interests as new generation of anticancer molecules and were recognized by multidrug resistant transporters such as P-glycoprotein and MRP1 protein. Of relevance to their use as anticancer agents alone or in combination with other agents, this study aims to analyze the interaction of the compounds with the MDR transporters including … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 9,670 accessesView PDFCite
Research ArticleOpen accessIn the keywordsP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDiatrizoate, Iopromide and Iotrolan Enhanced Cytotoxicity of Daunorubicin in Multidrug Resistant K562/adr Cells: Impaired the Mitochondrial and Inhibited the P-Glycoprotein FunctionNitaya Snitwongse Na Ayudhya, Samlee MankhetkornMultidrug resistance was an obstacle in cancer chemotherapy because the cells decreased their intracellular drug accumulation by energy-dependent compounds efflux pumps such as P-glycoprotein (P-gp). This study observed some iodinated radiographic contrast media, diatrizoate, iopromide and iotrolan affected the cellular energetic state and the kinetics of P-gp in drug-sensitive K562 and drug resistant K562/adr cell lines using spectrophotometer and spectrofluorometer. … …American Journal of Applied Sciences, Vol. 6, Issue 3 · 31 Mar 2009 · 7,161 accessesView PDFCite