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20 articles for “Liver Injury”
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Research ArticleOpen accessPhrase in the titleEvidences of Apoptosis in Hepatitis C Virus-Infected Hepatocytes and Peripheral Blood Monocuclear Cells in the Absence of Liver InjuryViviana Falcón, Nelson Acosta-Rivero, Mineko Shibayama et al.Understanding the mechanism of Hepatitis C Virus (HCV) pathogenesis is an important part of HCV research. In this study, the presence of apoptosis in HCV-infected liver and Peripheral Blood Mononuclear Cells (PBMC) from patients positive for anti-HCV antibodies and negative for serum HCV-RNA was investigated. The samples obtained from 21 patients were studied by in situ Hybridization (ISH), Immunofluorescence, TUNEL … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,975 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIntravenous Injection of Umbilical Cord-Derived Mesenchymal Stem Cells Improved Regeneration of Rat Liver after 2AAF/CCl4-Induced InjuryIsabella Kurnia Liem, Reni Oktavina, Zakiyah et al.The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 10 Jun 2021 · 6,780 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHepatoprotective Impact Of TLR9 Antagonist ODN 2088 Against Carbon Tetrachloride (CCl4)-Induced Hepatic InjuryBadr AlzahraniThe main objective of this study is to evaluate the hepatoprotective impact of TLR9 antagonist ODN 2088 against carbon tetrachloride (CCl4)-induced acute liver injury. In this study, 24 mice were grouped into four groups. CCl4 was introduced in all groups except for the control group intraperitoneally after pretreatment with ODN 2088 and silymarin for seven days. To assess the liver … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 4 Jan 2020 · 7,659 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunomodulatory and Antioxidant Effects of Stachys Japonica Miq. Ethanol Extract on Cyclophosphamide-Induced Immunosuppressed Mice and its Phytochemical CompositionXueping Jiang, Jianglong He, Yanjun Chen, Fang WangStachys japonica Miq. is an edible wild botanical drug and a traditional medicine in China. This study focused on examining the phytochemical profile and antioxidant properties of the ethanol extract of S. japonica Miq (SJEE) in vitro, as well as its immunomodulatory and antioxidant activities in cyclophosphamide (Cy)-induced immunosuppressed mice. The SJEE was analysed by UPLC-HRMS/MS. 36 Polyphenols, including flavonoids, … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 13 Apr 2026 · 1,449 accessesView PDFCite
Research ArticleOpen accessIn the abstractAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,449 accessesView PDFCite
Research ArticleOpen accessIn the abstractTrilobatin Possesses Protective Potentials on H2O2-Induced HepG2 Cells by Suppressing Oxidative Stress: Involvement of Nrf2/Keap1 Signal PathwayYuhan Zhai, Yuqing Zhang, Yaping Li et al.Trilobatin, a natural dihydrochalcone compound, possesses various biological activities. However, few investigations have been carried out on the mechanisms of trilobatin against oxidative stress. To comprehend the effects and mechanism of trilobatin on oxidative stress after hepatic injury, H2O2-induced HepG2 cells were used in this research. The results indicated that trilobatin enhanced the viability and improved the apoptosis morphology of … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 4 · 22 Dec 2023 · 5,087 accessesView PDFCite
Research ArticleOpen accessIn the abstractOrlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female RatsHaneen Mushtaq Hameed, Ahmed Flayyih Hasan, Zainab Haytham Razooki et al.Obesity has been linked to several chronic diseases, including fatty liver disease, fatty heart disease, diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was to determine how Orlistat affected renal toxicity, DNA damage, and apoptosis that were brought on by obesity in normal and obese female rats. There were four groups made up of … …OnLine Journal of Biological Sciences, Vol. 23, Issue 1 · 18 Jan 2023 · 5,831 accessesView PDFCite
Case ReportOpen accessIn the abstractHepatitis B-Related Mononeuritis MultiplexBudha Charan Singh, Vinay N Gowda, Prasan Kumar PandaHepatitisB Virus (HBV) infection can present with varied multisystem manifestationsinvolving the skin, kidneys, blood, and nervous system. We report a 57-year-oldman with HBV-related mononeuritis multiplex who had symptoms of multiplesensory-motor axonal polyneuropathies. He was evaluated for his neuropathy withnerve conduction studies and a sural nerve biopsy that revealed necrotizingsmall-vessel vasculitis. He also hadan acute liver injury. He was started on … …American Journal of Infectious Diseases, Vol. 18, Issue 4 · 16 Nov 2022 · 5,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic InflammationAhmed F. Hasan, Thulfiqar F. Mutar, Ehab Moustafa Tousson, Shatha Ghazi FelembanTricyclic Antidepressants Including Amitriptyline (AMI), stop the reabsorption of norepinephrine and serotonin, so the levels of transmitters is elevated in the brain to lead to several side effects. Therefore, current study aimed to assay liver dysfunction that attended by AMI administration and monitoring of damiana Turnera diffuse role as adjuvant therapy to improving amitriptyline hepatic effects in male rats. 60 … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 Jun 2021 · 8,286 accessesView PDFCite
Case ReportOpen accessIn the abstractEpistein-Barr Virus Infection with Concurrent Pancreatitis and Hepatitis: A Rare Disease EntityJered Cook, Megha Kothari, Andrew NguyenConcurrent acute hepatitis and acute pancreatitis is a rare disease entity. Most commonly it can be attributed to infectious etiologies such as hepatitis A, Hepatitis B and Hepatitis E. Although not as common, Epstein Barr Virus (EBV) should be considered in the differential diagnosis in patients with combined hepatitis and pancreatitis. We report a case of a 25 year-old male … …American Journal of Infectious Diseases, Vol. 11, Issue 3 · 18 Sep 2015 · 7,835 accessesView PDFCite