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9 articles for “Lethal Dose 50 (LD50)”
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Research ArticleOpen accessIn the keywordsDevelopment and Evaluation of Acaricidal Soap Formulated from Azadirachta indica (Neem) and Carica Papaya (Papaya) Leaf Extracts Using Bio-Assay Guided ApproachAlfredo V. Corpuz, Carmela Montoya Florentino, Ace Danielle C. AveroThe environment, human health, and animals are all at risk as a result of the pervasive use of chemical-based products to control ticks and lice in animals, mostly dogs. This investigation was designed to assess the efficacy and physicochemical properties of an acaricidal soap for canines that was formulated using Azadirachta indica and Carica papaya leaf extracts. The soap was … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 27 Nov 2025 · 3,082 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolluscicidal Activity of Ethanolic Dieffenbachia seguine (Dumb Cane) Leaf Extract Against Pomacea canaliculata (Golden Apple Snail)Alfredo V. Corpuz, Carmela M. Florentino, Ace Danielle C. Avero, Sherwin V. AlvaroThe golden apple snail (Pomacea canaliculata), an invasive species that originated in South America, has caused significant damage to rice plantations in Southeast Asia, notably the Philippines. Because of its voracious appetite for aquatic vegetation and quick reproduction rate, it poses a significant agricultural problem. Conventional control approaches, which mostly use chemical molluscicides, have increased environmental issues and threats to … …OnLine Journal of Biological Sciences, Vol. 26, Issue 3 · 14 Sep 2026 · 846 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Purified Tick Saliva Toxins on Various Bio-Molecules in Blood Serum, Liver and Muscles of Albino MiceNidhi Yadav, Ravi Kant UpadhyayIn the present study, salivary toxins from Rhipicephalus microplus were isolated and purified on a Sepharose CL 6B 200 gel column at a constant flow rate with regular fractions of 5 mL/min. Pooled fractions were lyophilized and LD50 was then determined in albino mice. The LD50 value of the protein toxin of Rhipicephalus microplus was found 36.11 mg/kg body weight … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 1 · 30 Dec 2023 · 5,354 accessesView PDFCite
Research ArticleOpen accessIn the abstractRadiosensitivity Assessment and the Impact of Gamma Radiation on the Growth and Diversity of Pennisetum purpureum Cv Mot in Marginal LandBela Putra, Budi PrasetyaThis study aims to assess the radiosensitivity of Pennisetum purpureum cv Mott, with the primary objectives of determining the LD50 value, evaluating the effects of gamma radiation doses on plant growth and diversity, and elucidating the specific goals of irradiation in relation to the overall research. The research encompasses a wide range of radiation doses, ranging from 0-400 Gy, including … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 1 · 20 Dec 2023 · 5,641 accessesView PDFCite
Research ArticleOpen accessIn the abstractExploration of Antidiabetic and Hypolipidemic Activity of Roots of Croton ZambesicusPrakash Kumar, Rahul Kumar, Manoj Kumar Rastogi, Krishna MurtiThe aim of this study was to investigate the potential antidiabetic and hypolipidaemic effects of aqueous and ethanolic extracts of roots of Croton zambesicus in alloxan induced diabetic models to ascertain its pharmacological applicability. The roots of Croton zambesicus were collected, dried and extracted. The phytochemical screening as well as Median Lethal Dose determination (LD50) was done. The ethanolic extract … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 1 · 12 Jun 2017 · 7,851 accessesView PDFCite
Research ArticleOpen accessIn the abstractIN VIVO ANTIPLASMODIAL ACTIVITY AND ACUTE TOXICITY OF STANDARDIZED EXTRACT OF EURYCOMA LONGIFOLIA JACK. ROOT TRADITIONALLY USED TO TREAT MALARIAEti Nurwening Sholikhah, Mahardika Agus Wijayanti, MustofaA series of studies has been conducted to prove the Eurycoma longifolia Jack. root as an antimalarial. However, the in vivo antiplasmodial activity of E. longifolia Jack. root standardized extract and its lethal dose 50% (LD50) values is unknown. In vivo antiplasmodial activity was conducted on Plasmodium berghei infected Swiss mice as malaria model with 4-day suppression methods. Sixty mice … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 27 Dec 2013 · 7,732 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Evaluation of Aspilia Africana Leaf Extracts in MiceO. O.K. Oko, E. A. Agiang, E. E. Osim, O. R. AsuquoProblem statement: The degree of toxicity of crude extracts of Aspilia Africana (Bush marigold) leaf on the basis of routes and dosages of administration were investigated. 204 healthy, male Swiss albino mice (20-25g) were used in three consecutive studies. Approach: In the first and second study, oral and intraperitoneal doses of 100, 500, 1000, 2000 and 4000 mg kg-1 body … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 28 Nov 2011 · 8,184 accessesView PDFCite
Research ArticleOpen accessIn the abstractGamma Radiosensitivity Study on Chili (Capsicum annuum)Shairul Rizdiyandi Omar, Osumanu Haruna Ahmed, Shaharudin Saamin, Nik Muhamad Ab. MajidInduced mutation by gamma irradiation has been found to be a very useful technique for crop improvement. Apart from this, the proper use of induced mutation in plant breeding has become a profitable approach. This investigation was carried out to determine the LD50 and effect of gamma rays on germination, plant height, survival percentage, root length, root dry weight and … …American Journal of Applied Sciences, Vol. 5, Issue 2 · 28 Feb 2008 · 9,033 accessesView PDFCite
Research ArticleOpen accessIn the abstractGamma Radiosensitivity Study on Long Bean (Vigna sesquipedalis)Ellyfa Kon, Osumanu Haruna Ahmed, Shaharudin Saamin, Nik Muhamad Ab. MajidThis study was conducted to determine the LD50 and effect of gamma ray on germination percentage, plant height, survival percentage, root length, root dry weight and shoot dry weight of seedlings derived from seeds of long bean (Vigna sesquipedalis). Seeds of this crop were treated with 300, 400, 500, 600 and 800 Gy gamma rays at Malaysian Institute of Nuclear … …American Journal of Applied Sciences, Vol. 4, Issue 12 · 31 Dec 2007 · 8,596 accessesView PDFCite