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13 articles for “Haplotype”
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Research ArticleOpen accessEvery word in the titleThe COXII Haplotypes and their Association with Productive Traits in Large White Breed PigsMaria A. Kolosova, Lyubov V. Getmantseva, Nekruz F. Bakoev et al.The mitochondrial genome encodes key electron transfer chain (ETC) proteins which produce the vast majority of cellular ATP. Sequence analysis of maternal inherited mitochondrial DNA is an effective way to assess the individual characteristics of commercial breeding lines of pigs. The aims of our study were to analyze the nucleotide sequence of the mitochondrial gene COXII in Large White pigs, … …OnLine Journal of Biological Sciences, Vol. 19, Issue 3 · 2 Jul 2019 · 7,655 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMinimum Free Energy Based Evaluation of mRNAs Secondary Structures Constructed by 18 Clinically Significant Exonic Single Nucleotide Polymorphisms (SNPs) and Haplotypes of 5 Missense SNPs of RB1 GeneSarder Nasir Uddin, Apurba Majumder, Khandker Khaldun Islam et al.Clinically significant 18 Single Nucleotide Polymorphisms (SNPs) from exon regions of Retinoblastoma gene (RB1) were analyzed to find out the structural variations in mRNAs. Online bioinformatic tools i.e., Vienna RNA, RNAfold were used for secondary structure analysis of mRNAs. Predicted minimum Free Energy Change (MFE) was calculated for mRNAs structures. It has been observed that the average of predicted MFE … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 4 · 21 Oct 2015 · 8,556 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBayesian Determination of Disease Associated Differences in Haplotype BlocksIvan Kozyryev, Jing ZhangProblem statement: While experimental ascertainment of haplotype blocks in the genome-scale case-control studies is expensive, accurate computational phasing is still a daunting task for bioinformatics approaches. We used a statistical method to determine differences, potentially associated with a certain disease, in linkage disequilibrium block boundaries in whole-genome Single Nucleotide Polymorphisms (SNPs) data. Approach: We utilized a Bayesian model for calculating … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 14 Feb 2012 · 8,423 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGenetic Characterization of Kazakh Native Sheep Breeds Using Mitochondrial DNAIlmira Mukhametzharova, Yessenbay Islamov, Saukymbek Shauyenov et al.In this study, we used mitochondrial (mt) DNA to reveal patterns of genetic diversity among six breeds of sheep native to Kazakhstan, including the Chu and Kalchengel types of Kazakh mutton-semifine-wool breed of sheep, Akzhayik, Edilbay, Kazakh fat-rumped semi-course-wool and South Kazakh Merino breeds. Mitochondrial DNA D-loop was studied in 64 samples to determine the genetic diversity of the local … …OnLine Journal of Biological Sciences, Vol. 18, Issue 3 · 7 Sep 2018 · 8,848 accessesView PDFCite
Research ArticleOpen accessIn the keywordsStudy on Follicle Stimulating Hormone Receptor Gene Polymorphisms in South Indian Women with Polycystic Ovarian SyndromeHimavanth Reddy Kambalachenu, Solomon Franklin Durairaj Paul, Sanjeeva Reddy Nellepalli, Perumal VenkatachalamPolycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder of women in their reproductive ages. Though PCOS is a complex, heterogeneous disorder, but there is strong evidence for its genetic predisposition. The aim was to study the association of Follicle Stimulating Hormone Receptor (FSHR) gene polymorphisms rs1394205, rs6165 and rs6166 in south Indian women with PCOS. The present case … …Current Research in Medicine, Vol. 4, Issue 2 · 4 Sep 2013 · 12,695 accessesView PDFCite
Research ArticleOpen accessIn the keywordsComparative Analysis of UGT1A9 Genetic Polymorphisms between Chinese Han and Tibetan PopulationsWei Yan, Jian Cui, Yuewen Wang et al.Although various polymorphisms have been identified in the UGT1A9 gene in the main sorts of ethnic groups in the world, no investigations have been focused on the Chinese Tibetan populations and the comparison between Chinese Tibetan and Han populations to date. This study was designed to systematically compare genetic differences between the two populations. We investigated the functional regions of … …Current Research in Medicine, Vol. 3, Issue 2 · 23 Aug 2012 · 7,641 accessesView PDFCite
Research ArticleOpen accessIn the keywordsQTL Mapping Using Multiple Markers SimultaneouslyD. Kolbehdari, J.A.B. RobinsonMethods for detecting and locating a single QTL within a 10 cM region of DNA using 10 equally spaced SNP markers were compared. The QTL was assumed to be bi-allelic and located between markers 5 and 6. Monte Carlo simulation of a granddaughter design with 30 sires and 400 sons was used. Linear regression nested within sire using either two … …American Journal of Agricultural and Biological Sciences, Vol. 2, Issue 3 · 30 Sep 2007 · 7,110 accessesView PDFCite
Research ArticleOpen accessIn the keywordsForensic Evidence for Cytochrome b Gene SNPs in Obese and Non Obese Saudi ArabiansSayed Amin Mohamed Amer, Bandar Raddat Allah AlHothali, Monira Hmoud Alotaibi, Salah Mohamed TubaigyOral swabs from obese and non obese Saudi Arabians from both sexes with an average age of 35 years old were collected and their DNAs were extracted. PCR for 1000 bp of the mitochondrial cytochrome b (cytb) gene was conducted and the amplified products were sequenced in order to determine the possible forensic or obesity-related SNPs. Alignment of the obtained … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 9 Mar 2018 · 9,380 accessesView PDFCite
Research ArticleOpen accessIn the abstractEstimating the Genetic Polymorphisms of Gujarat Population using 17 Y Chromosomal STR lociAditi Mishra, Ulhas Gondhali, Sumit ChoudharyThe present study aims to report genetic variations in unrelated male (n = 118) of the Gujarat population with the help of seventeen Y-STR markers (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y GATA H4, DYS437, DYS438 and DYS448). Allele frequencies and forensic parameters were calculated. A total of 96 distinct alleles were reported with … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 23 Jun 2021 · 6,504 accessesView PDFCite