6 articles for “Genome-wide association study”

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Research ArticleOpen accessPhrase in the titleEffectiveness of the Use of Genetic Markers of Meat Productivity in the Kazakh White-Headed Breed Identified Using Genome-Wide Association StudyIndira Beishova, Askar Nametov, Alzhan Shamshidin et al.The study aimed to determine the effectiveness of the use of genetic markers in cattle of the Kazakh white-headed breed identified using a genome-wide association study. The object of the study was the livestock of 790 Kazakh white-headed bulls bred in breeding farms of the Republic of Kazakhstan. The study adheres to rigorous ethical standards, with all procedures approved by … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 25 Jun 2024 · 5,023 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleGenome-Wide Association Study of Single Nucleotide Polymorphisms with Milk Traits in Red Gorbatov CattleMarina Ivanovna Selionova, Grigorii Sergeyevich Shekhovtsev, Ivan Petrovich Prokhorov et al.In order to preserve the gene pool of the Red Gorbatov breed, it is necessary to use a set of genomic analysis tools that allows more efficient planning in obtaining individuals who meet the economic requirements of dairy farming. The aim of the work was to identify candidate genes associated with milk production traits in Red Gorbatov cattle using a … …American Journal of Animal and Veterinary Sciences, Vol. 19, Issue 4 · 12 Oct 2024 · 4,736 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsBayesian Exploration of Multilocus Interactions on the Genome-Wide ScaleIvan Kozyryev, Jing ZhangProblem statement: Recent technological and scientific advances propelled the field of Genome-Wide Association Study (GWAS), which promises to be instrumental in linking many common complex diseases to their genetic origin. While so far such large-scale surveys have been moderately successful in identifying disease related genetic variants, much of disease heritability is still not accounted for by the discovered loci. There … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 2 Jul 2012 · 7,401 accessesView PDF Cite

EditorialOpen accessIn the abstractBig Data and Parkinson’s Disease - from Understanding of Disease to Personalised MedicineYen F. Tai, Nicola PaveseThe advancement of information technology in recent years has generated a huge amount of datasets in all areas of scientific research. This has led to new opportunities to harness the 'Big Data' to improve our understanding of diseases - from investigating disease mechanisms to monitoring treatment responses. The Big Data approach is a data-driven and often hypothesis-free, way of studying … …Neuroscience International, Vol. 7, Issue 1 · 27 Jul 2016 · 7,755 accessesView PDF Cite

Research ArticleOpen accessIn the abstractHigh-Order Interactions in Rheumatoid Arthritis Detected by Bayesian Method using Genome-Wide Association Studies DataJing Zhang, Zheyang Wu, Chao Gao, Michael Q. ZhangProblem statement: In order to reveal the missing genetic component of Rheumatoid Arthritis (RA) susceptibility, we carried out a genome-wide high-order epistatic interaction study for RA. Approach: A powerful Bayesian strategy was applied to analyze the data of Genome-Wide Association Studies (GWAS) from the Welcome Trust Case Control Consortium (WTCCC), where 319 high-order interactions were found across the whole genome … …Current Research in Medicine, Vol. 3, Issue 1 · 30 Mar 2012 · 8,379 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordA Bayesian Method for Disentangling Dependent Structure of Epistatic InteractionJing Zhang, Qu Zhang, Darrin Lewis, Michael Q. ZhangProblem statement: We propose a Bayesian method (RBP) to recursively infer the independence structure of epistatic interactions in case-control study. Approach: Based on the results of BEAM2, RBP can powerfully detect the marginal and conditional independence within interacting SNPs even in the complicated interaction cases. Results: We did extensive simulations to test RBP and compare it with stepwise logistic regression. … …Current Research in Biostatistics, Vol. 2, Issue 1 · 13 Jan 2012 · 7,476 accessesView PDF Cite