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16 articles for “Gene expressions”
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Research ArticleOpen accessIn the keywordsEfficient Classification of Cancer using Support Vector Machines and Modified Extreme Learning Machine based on Analysis of Variance FeaturesA. Bharathi, A.M. NatarajanProblem statement: The primary objective is to propose efficient cancer classification techniques which provide reliable and significant classification accuracy. To achieve this primary research goal is to find the smallest set of genes that can ensure high accuracy in classification using supervised machine learning algorithms. The significance of finding the minimum subset is three fold: (a) The computational burden and … …American Journal of Applied Sciences, Vol. 8, Issue 12 · 22 Oct 2011 · 7,441 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCancer Classification using Support Vector Machines and Relevance Vector Machine based on Analysis of Variance FeaturesA. Bharathi, A.M. NatarajanProblem statement: The objective of this study is, to find the smallest set of genes that can ensure highly accurate classification of cancer from micro array data by using supervised machine learning algorithms. The significance of finding the minimum subset is three fold: The computational burden and noise arising from irrelevant genes are much reduced; the cost for cancer testing … …Journal of Computer Science, Vol. 7, Issue 9 · 25 Jul 2011 · 7,593 accessesView PDFCite
Research ArticleOpen accessIn the abstractComputational Prediction of Diabetic Nephropathy-Associated Comorbidities and Their Key Genes by Analyzing RNA-Seq DataChaity Paul, Md. Ashiq Uddin, Rupa Dey et al.Diabetic Nephropathy (DN) is a complex health condition that leads to various kidney diseases. According to the World Health Organization, over 2 million deaths have been reported due to diabetes and diabetes related kidney diseases in 2021. And at the recent 78th World Health Assembly, chronic kidney disease was reported to be one of the most common diabetes-related complications, and … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 19 May 2026 · 1,667 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Metallothionein-Like Protein 2B Gene Induced by Different Concentrations of Copper in White Spruce (Picea glauca)Megan McKergow, Kabwe NkongoloThe alterations to the expressions of metal transporter genes can induce metal ion uptake to maintain cell homeostasis when metal concentrations are low. Metallothioneins (MTs) are a class of low molecular mass (4-8 kDa), cysteine (Cys)-rich proteins that can bind metals via the thiol groups of their Cys residues. Studies on MT gene expressions in higher plants, such as conifers, … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 25 Dec 2022 · 5,118 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Dynamic of Afamin and Alpha-Fetoprotein Expression during Rat Liver DevelopmentIndriyani, Isabella Kurnia Liem, Puspita Eka Wuyung et al.Liver has a high level of Alpha-fetoprotein which is assumed to be important for mammalian development. However, Alpha-fetoprotein knockout studies in mice suggested that despite the absence of Alpha-fetoprotein, mice developed normally; the only abnormality observed was infertility in female mice. There are indications that Afamin, a protein that has a gene sequence located on the same chromosome as Alpha-fetoprotein, … …OnLine Journal of Biological Sciences, Vol. 21, Issue 1 · 5 Feb 2021 · 6,766 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelative Transcription Expression Level of SIRT1, SIRT2 and SIRT3 in Correlation to the Expression of a Set of Selected Cancer Related Genes in Human Breast CancerHamdy Swelim, Omnia Mansour, Salah Abdel-Rahman et al.Mammalian Sirtuins have been shown to perform distinct cellular functions and deregulated expression of these genes was reported to be involved in the development of various malignancies including breast cancer. An increasing number of evidence indicates that Sirtuins have both tumor promoter and tumor suppressor functions. However, the roles of Sirtuins have not been well-studied in breast cancer. In the … …OnLine Journal of Biological Sciences, Vol. 18, Issue 2 · 18 Jan 2018 · 7,476 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin Promotes the Expression of Genes Involved in Phagocytosis in Bovine NeutrophilsSuphakit Srikok, Sukij Nambut, Kanruethai Wongsawan, Phongsakorn ChuammitriThis study was conducted to explore the effect of Quercetin (QH) on phagocytosis of bovine neutrophils. Neutrophils were isolated from fifteen multiparous Holstein cows. We in vitro treated neutrophils with PBS or 50 µM of Quercetin (QH) or Cytochalasin B (CytB), as phagocytosis inhibitor, prior to monitoring phagocytosis of Escherichia coli by flow cytometry and microscopic examination. Additionally, the expressions … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 2 Aug 2017 · 8,120 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Silencing of Septin 1 via Synthetic siRNAs in Schizosaccharomyces pombeSemih Ekimler, Merve Yilmazer, Ercan AricanSeptins are evolutionary conserved GTP-binding proteins and form heterooligomers in cells to interact with cytoskeleton. The main roles of septins in cell are cytokines, membrane interactions, vesicle trafficking and microtubule and actin organization. Non-coding RNAs are key players of gene expression regulation. Small-interfering RNAs (siRNAs) belong to non-coding RNAs, are characterized by sequence complementarity to their target mRNAs. siRNAs silence … …OnLine Journal of Biological Sciences, Vol. 17, Issue 1 · 31 Mar 2017 · 7,237 accessesView PDFCite
Research ArticleOpen accessIn the abstractPOTENTIAL AMELIORATIVE ROLE OF N-ACETYLCYSTEINE AGAINST TESTICULAR DYSFUNCTION INDUCED BY TITANIUM DIOXIDE IN MALE ALBINO RATSAhmed Farag El-Kirdasy, Mohamed Abdo Nassan, Ahmed Abdel Aziz Baiomy et al.In this study, we examined the ameliorative action of N-Acetylcysteine (NAC) against Titanium Dioxide (TiO2) induced testicular degeneration in albino rats. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg-1 BW), NAC (100 mg kg-1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Testicular tissues were extracted for … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 31 Dec 2013 · 7,900 accessesView PDFCite
Research ArticleOpen accessIn the abstractCinnamon Extract Regulates Gene Expression of Lipid and Carbohydrate Metabolism in Streptozotocin Induced Diabetic Wistar RatsMohamed Mohamed Soliman, Mohamed Mohamed Ahmed, Samir Ahmed El-ShazlyCinnamon is a herbal medication plant used widely for many diseases in the Middle East and ancient countries. Cinnamon Extract (CE) contains many active substances that modulate insulin sensitivity and acts as anti-diabetic medication. Diabetes mellitus is a disease characterized by disturbance in carbohydrate and lipid metabolism. The aim of this study was to examine the effect of Cinnamon Extract … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 8,043 accessesView PDFCite