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13 articles for “Extended-Spectrum-β-Lactamase”
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Research ArticleOpen accessEvery word in the titleStrains of Klebsiella Pneumoniae from Intensive Care Unit Producing CTX-M-15 Extended Spectrum Beta LactamasesI.R. Iroha, A.E. Oji, A.E. Nwakaeze et al.Problem statement: Resistance to third generation cephalosporins due to acquisition and expression of Extended Spectrum β-Lactamase (ESBL) among Gram-negative bacteria is on the increase. Infections involving extended spectrum beta lactamase bacteria are associated with significant morbidity and mortality. Therefore, infections due to ESBL isolates continue to pose a serious challenge to infection management worldwide. Since screening for ESBL is not … …Current Research in Microbiology, Vol. 2, Issue 2 · 6 Mar 2012 · 7,826 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntimicrobial Pattern and Clonal Dissemination of Extended-Spectrum Beta-Lactamase Producing Klebsiella Spp IsolatesSobhan Ghafourian, Nourkhoda Sadeghifard, Zamberi bin Sekawi et al.Problem statement: Gram-negative pathogens harboring ESBLs have caused numerous outbreaks of infections and are becoming an increasing therapeutic problem in many countries. The incidence of ESBL-producing strains among clinical isolates has been steadily increasing over the past years resulting in limitations of therapeutic option. The focus of this study was to examine the molecular epidemiology of ESBL-producing Klebsiella spp, investigate … …American Journal of Infectious Diseases, Vol. 6, Issue 4 · 31 Dec 2010 · 7,898 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleExtended-Spectrum β-Lactamases Producing Escherichia coli Strains Monitored Over 4 Years in The University Hospital in Košice, SlovakiaViera Lovayová, Lucia Vargová, Mária Nagyová et al.The beta-lactamases with extended spectrum of activity (ESBL) are medically one of the most important group of enzymes. The presented study provides identification and determination of the spectrum of resistance against different and clinically used antimicrobial drugs in the clinical isolates of Escherichia coli. These isolates had their origin in different departments of the University Hospital L. Pasteur in Košice. … …Current Research in Microbiology, Vol. 7, Issue 1 · 16 Jun 2016 · 14,537 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSusceptibility and Detection of Extended Spectrum β-Lactamase Enzymes from Otitis Media PathogensEjikeugwu Chika, Iroha Ifeanyichukwu, Adikwu Michael, Esimone CharlesOtitis media is the bacterial infection of the middle ear usually accompanied with inflammation, effusions and pain. It can present clinically in two major forms: Acute Otitis Media (AOM) and Otitis Media with Effusion (OME) and it is one of the leading cause of hospital visits and antibiotic prescriptions amongst children and even adults. Antibiotic resistance is a global public … …American Journal of Infectious Diseases, Vol. 9, Issue 1 · 21 Mar 2013 · 7,970 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIdentification of Clonal Clusters of Klebsiella pneumoniae Isolates from Chennai by Extended Spectrum Beta Lactamase Genotyping and Antibiotic Resistance Phenotyping AnalysisC. Kamatchi, H. Magesh, Uma Sekhar, Rama VaidyanathanProblem statement: An increased resistance to antibiotics has been reported in Klebsiella pneumoniae, an opportunistic gram negative pathogen belonging to Entrobacteraceae due to the evolution and spread of plasmid encoded extended spectrum beta lactamases and other genes conferring cross-resistance to other antibiotics. This is of concern due to the increasing cost of antibiotic treatment and the spread of multidrug resistance … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,953 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePharmacodynamic Comparison of the Carbapenems Against E. coli and Klebsiella spp. Containing Extended spectrum β-lactamasesKathryn J. Eagye, Joseph L. Kuti, David P. NicolauCarbapenems are the treatment of choice for extended-spectrum β-lactamases (ESBLs). Ertapenem is a new member of the carbapenem class, and is often grouped with imipenem and meropenem as a recommended treatment for ESBLs. However, new in vitro data question ertapenem’s inclusion as a first line treatment for these bacteria, suggesting that ertapenem has a lower likelihood of obtaining appropriate pharmacodynamic … …American Journal of Infectious Diseases, Vol. 1, Issue 3 · 30 Sep 2005 · 6,886 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDetection of Extended-Spectrum β Lactamases and AmpC β-Lactamase Production in Escherichia coli Causing Urinary Tract Infection among HIV and Non-HIV PatientsPadmavathy Kesavaram, Padma Krishnan, Rajasekaran SikhamaniProblem statement: Opportunistic infections have been documented as a leading cause of morbidity among HIV patients. Gram negative pathogens that elaborate beta-lactamases have been reported to be associated with increased morbidity and mortality, especially amongst immunocompromised patients on intensive care and high-dependency units. The most common mechanism of β-lactam drug resistance in Escherichia coli include ESBL, AmpC production. Approach: In … …Current Research in Medicine, Vol. 2, Issue 1 · 18 Aug 2011 · 7,834 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPhenotypic ESBL Detection in Acinetobacter baumannii: A Real ChallengeGeetanjali M. Litake, Vikram S. Ghole, Krishna B. Niphadkar, Suresh G. JoshiClinical Laboratory Standards Institute (CLSI) recommends two-step approach for extended-spectrum-β-lactamase (ESBL) detection which includes the screening of recommended agents and the phenotypic confirmation of ESBL using a combination of screening agent and β-lactamase inhibitor. To investigate this approach, we screened 145 β-lactamase-producing Acinetobacter baumannii isolates for ESBL from tracheal secretions using double disk synergy test (DDST) and phenotypic confirmatory disc … …American Journal of Infectious Diseases, Vol. 11, Issue 3 · 19 Oct 2015 · 7,771 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntibacterial Activity of Marine Source Extracts Against Multidrug Resistance OrganismsNagi A. AL-Haj, Nurmas I. Mashan, Mariana N. Shamsudin et al.Problem statement: Antimicrobial resistance is the major problem of global dimensions with a significant impact on morbidity, mortality and healthcare-associated costs. The problem has recently been worsened by the steady increase in multiresistant strains and by the restriction of antibiotic discovery and development programs. Methicillin-resistant Staphylococcus aureus, pseudomonads and Escherichia coli are a major nosocomial and community-acquired pathogens for which … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 10,073 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparison of Diagnostic Tests for Fosfomycin Resistance Detection in Clinically Significant EnterobacteralesSantoshi Maruti Naik, Biranthabail Dhanashree, Himani KotianMultidrug resistance in Enterobacterales has triggered interest in old antibiotics like fosfomycin. Various methods to determine fosfomycin resistance are time-consuming and yield unpredictable results. Hence, the study was undertaken to compare the rapid fosfomycin NP test with the recommended agar dilution test and few other tests. In this cross-sectional, time-bound, prospective study, Enterobacterales (N = 110) were tested for their … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 21 Nov 2025 · 2,113 accessesView PDFCite