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Research ArticleOpen accessIn the keywordsInfluence of Quercetin on Diabetes-Induced Alteration in CYP3A Activity and Bioavailability of Pioglitazone in RatsSudhir Niranjan Umathe, Pankaj Vinod Dixit, Jignesh Manubhai Vaghasiya, Nishant Sudhir JainProblem statement: Quercetin-a common bioflavonoid, is present in herbal preparations consumed by diabetic patients along with routine anti-diabetic agents. We recently showed that quercetin increases the bioavailability of pioglitazone in non-diabetic rats. Thus, present study investigated whether this pharmacokinetic interaction is also evident in diabetic animals, especially because diabetic subjects have altered gastrointestinal (GI) function and CYP3A activity. Approach: The … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,818 accessesView PDFCite