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14 articles for “Dose-dependent Toxicity”
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Research ArticleOpen accessEvery word in the titleAntioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in RatsMd. Yousuf Ali, Md. Reaz Morshed, Md. Sakib Hossen et al.In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxidant power. Administration of paracetamol (500 mg/kg) for seven consecutive days caused severe oxidative stress in … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 26 Nov 2018 · 8,337 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,241 accessesView PDFCite
Research ArticleOpen accessIn the abstractAccumulation and Effect of Manganese on Chloroplasts and Antioxidant Responses in Arabidopsis ThalianaJun Xing, Xue Yang, Cailing YuanIn this study, 5-day-old seedlings of Arabidopsis thaliana were exposed to 0, 0.5, and 1.0 mmol/L MnCl₂ for 6 days by using three independent biological replicates. The results indicated that Mn content in roots exhibited a dose-dependent increase with rising external Mn supply. The elevated Mn levels led to significant reductions in the nutrient content of K, Ca, Na, and … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 18 Jul 2026 · 824 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Dietary Emamectin Benzoate at Recommended and Overdose Levels on the Pathophysiological Responses and Tolerability of Oreochromis niloticus at Fry StageJasmine Singha, Thangapalam Jawahar Abraham, Satyen Kumar Panda, Prasanna Kumar PatilEmamectin Benzoate (EB) has been recommended as a feed additive for the control of fish ectoparasites. This investigation examined the impact of dietary EB on physiological responses, antioxidant defence mechanisms, and histopathological changes in key organs, and on the kinetics of residue deposition and elimination in the muscle of Oreochromis niloticus fry. Fry were administered EB feeds at 50 µg … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 1 Jul 2026 · 1,469 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe interplay between Cadmium and Zinc Induced Developmental Perturbations and Apoptosis in Daphnia MagnaNaima Hamid, Siti Nur Airina Binti Ibrahim et al.Assessing combined toxicity provides a realistic and comprehensive approach to determining toxicological effects in aquatic species under environmentally relevant conditions. This study was conducted to understand the effects of single and combined metal mixtures on freshwater flea and Daphnia magna. Environmentally Relevant Concentrations (ERCs) of Cadmium (Cd) and Zinc (Zn) at a low dose (10μg/L) and high dose (30 μg/L) … …American Journal of Environmental Sciences, Vol. 21, Issue 1 · 11 Jun 2025 · 6,015 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractCrude Extract of Blue-Green Pigment Derived from the Marine Bacterium Pseudomonas aeruginosa P1.S9 has Antibacterial, Antioxidant, and Cytotoxic ActivitiesAris Tri Wahyudi, Rahmah Nursari, Widya Esti Purwaningtyas et al.Pigment derived from marine bacteria is one of the alternative sources of natural products characterized by beneficial functions for pharmaceutical purposes. This study aimed to evaluate the antimicrobial, antioxidant and cytotoxic activities of the marine bacterium Pseudomonas aeruginosa P1. S9 crude pigment extract and identify its chemical content. Crude pigment extract of this bacterium showed promising antibacterial activities against Pseudomonas … …OnLine Journal of Biological Sciences, Vol. 22, Issue 1 · 4 Mar 2022 · 6,994 accessesView PDFCite
Research ArticleOpen accessIn the abstractApoptosis Inducer Capacity of Cardiotonic Steroids of Urginea maritima Extract on SH-SY5Y Neuroblastoma Cells, with Less Susceptibility among Neuron-Module CellsMaati M. Elghuol, Khalilah Abdul Khalil, Mazatulikhma Mat Zain, Mohamed Saifulaman Mohamed SaidNatural products have played a significant role in conventional treatment and in the development of new drugs for a wide range of illnesses, including malignant disease. Urginea maritima is classified as an herb is endemic to the Mediterranean area. This herb was renowned in traditional ethnopharmacological applications. Notwithstanding, there is a lack of evidence pertaining to the characterization of the … …American Journal of Applied Sciences, Vol. 13, Issue 5 · 28 May 2016 · 7,345 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,989 accessesView PDFCite
Research ArticleOpen accessIn the abstractZinc Phosphide Induced DNA Damage in the Blood Cells of Gallus sp. using Comet DNA AssayK. A. Muid, R. M. Shahjahan, R. Begum, R. A. BegumProblem statement: The comet DNA assay is considered a suitable and rapid test for DNA-damaging potential in environmental and biomonitoring studies. Approach: During the study comets were analyzed as a measure of DNA damage to quantify the damage in the blood cells of fowls (Gallus sp.) after exposure to Zinc Phosphide (Zn3P2). Here the potential for DNA strand breaks by … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 1 · 3 Mar 2012 · 8,953 accessesView PDFCite