2 articles for “Dihydrofolate reductase”

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Research ArticleOpen accessPhrase in the titleGenomic Distance between Thymidylate Synthase and Dihydrofolate Reductase Genes Does Not Correlate With Phylogenetic Evolution in BacteriaVitor Hugo MoreauProblem statement: Dihydrofolate Reductase (DHFR) and Thymidylate Synthase (TS) exist as bifunctional enzymes coded into unique polypeptide chain in protozoans. Bifunctional DHFR-TS is associated with an increase in the enzymatic activity by channeling the substrate between the active sites. In some bacteria, DHFR and TS genes are neighbors in the genome, whereas in others, they are located millions of base … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 8,188 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsDesign and Synthesis of Diaminotriazines as Anti-Tuberculosis DHFR InhibitorsArundhati C Lele, Archana Raju, M.K. Ray et al.A series of novel 2,4 diamino-s-triazine was designed as potential Mycobacterium tuberculosis (Mtb) Dihydro folate reductase inhibitors. The synthesized compounds were evaluated in whole cells by employing Resazurin Microtitre Plate Assay (REMA) against Mtb H37Rv, using known DHFR inhibitors Methotrexate and Trimethoprim as standard drugs. The most active compound in the whole cell assay was selected for DHFR enzyme assay … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,716 accessesView PDF Cite