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10 articles for “DNA damage response”
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Research ArticleOpen accessIn the keywordsStructural and Evolutionary Analysis of PARPs in D. discoideumA. Mehadvi Kawal, Hina A. Mir, Chethan Kumar Ramniklal et al.Problem statement: Dictyostelium discoideum, a unicellular eukaryote, exhibits multicellularity upon nutrient starvation, making it a better model for developmental studies and for the study of various signal transduction pathways. The most felicitous point of interest is that many of its genes show high degree of similarity to vertebrate genes. Poly (ADP-ribose) polymerase (PARP), a ubiquitous and abundant nuclear protein, has … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,852 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic InflammationAhmed F. Hasan, Thulfiqar F. Mutar, Ehab Moustafa Tousson, Shatha Ghazi FelembanTricyclic Antidepressants Including Amitriptyline (AMI), stop the reabsorption of norepinephrine and serotonin, so the levels of transmitters is elevated in the brain to lead to several side effects. Therefore, current study aimed to assay liver dysfunction that attended by AMI administration and monitoring of damiana Turnera diffuse role as adjuvant therapy to improving amitriptyline hepatic effects in male rats. 60 … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 Jun 2021 · 8,286 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,737 accessesView PDFCite
EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractRADIOSENSITIZATION OF CANCER STEM CELLS: TARGETING TGFβ, NOTCH OR TELOMERASE TO IMPROVE TUMOR RESPONSE O RADIOTHERAPYIgnacio Fernandez-GarciaRadiation resistant cancer stem cells are the main reason for treatment failure and tumor recurrence after cancer radiotherapy. Increasing biological evidences demonstrate that these cells possess the capacity to repair radiation induced DNA damage, protect themselves from radiation derived reactive oxygen species, survive and proliferate after several fractions of radiotherapy and finally, repopulate the heterogeneity of the tumor. Thus, targeting … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Jul 2014 · 7,459 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,989 accessesView PDFCite
Research ArticleOpen accessIn the abstractZinc Deficiency and Associated T-Cell Dysfunctioning among Human Immunodeficiency Virus SeropositivesM. Andrew Pradeep, M. Thiruvalluvan, V. Nalini, J. Stella MaryProblem statement: All the nutrients in the diet play a crucial role in maintaining an optimal immune response. In both, deficient and excessive intake of nutrients can have negative consequence on the immune status and susceptibility to a variety of pathogens. Zinc is an essential micronutrient for human growth development and immune function. It plays a vital role in structure … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 8,037 accessesView PDFCite
Research ArticleOpen accessIn the abstractBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,455 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic Triggers for Intervention in Aging, Disease and TraumaJoan Smith SonnebornHormesis refers to the ability of a chemical or physical agent to condition the physiological state of an organism to tolerate stress with low doses of otherwise harmful agents. Evolutionary evidence shows that the survival and longevity of species hinge on their optimal ability to resist stress challenge. Hormesis is a potent strategy to stimulate latent repair processes to tolerate … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,895 accessesView PDFCite